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DAP12 interacts with RER1 and is retained in the secretory pathway before assembly with TREM2
DNAX-activating protein of 12 kDa (DAP12) is a transmembrane adapter protein expressed in lymphoid and myeloid lineage cells. It interacts with...
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TOTEM: a multi-cancer detection and localization approach using circulating tumor DNA methylation markers
BackgroundDetection of cancer and identification of tumor origin at an early stage improve the survival and prognosis of patients. Herein, we...
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Lessons from the physiological role of guanosine in neurodegeneration and cancer: Toward a multimodal mechanism of action?
Neurodegenerative diseases and brain tumours represent important health challenges due to their severe nature and debilitating consequences that...
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A Ratiometric Benzimidazole-Based Fluorescent Probe for The Recognition of Phosgene in Solution and Gaseous Phases
Considering the high toxicity and widespread application of phosgene, there is an urgent need to develop a simple and sensitive method for detecting...
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Impact on Glycemia Risk Index and other metrics in type 1 adult patients switching to Advanced Hybrid Closed-Loop systems: a one-year real-life experience
BackgroundAdvanced Hybrid Closed-Loop system (AHCL) has profoundly changed type 1 diabetes therapy. This study primarily aimed to assess the impact...
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Unraveling the differential mechanisms of revascularization promoted by MSCs & ECFCs from adipose tissue or umbilical cord in a murine model of critical limb-threatening ischemia
BackgroundCritical limb-threatening ischemia (CLTI) constitutes the most severe manifestation of peripheral artery disease, usually induced by...
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Vitamin C inactivates c-Jun N-terminal kinase to stabilize heart and neural crest derivatives expressed 1 (Hand1) in regulating placentation and maintenance of pregnancy
Vitamin C (VC) serves as a pivotal nutrient for anti-oxidation process, metabolic responses, and stem cell differentiation. However, its precise...
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Therapeutic potential of transient receptor potential (TRP) channels in psychiatric disorders
Psychiatric disorders such as Bipolar disorder, Anxiety, Major depressive disorder, Schizophrenia, Attention-deficit/hyperactivity disorder, as well...
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FABP3 Induces Mitochondrial Autophagy to Promote Neuronal Cell Apoptosis in Brain Ischemia-Reperfusion Injury
This study elucidates the molecular mechanisms by which FABP3 regulates neuronal apoptosis via mitochondrial autophagy in the context of cerebral...
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Map** of Aegilops speltoides derived leaf rust and stripe rust resistance genes using 35K SNP array
Wheat is an essential food commodity cultivated throughout the world. However, this crop faces continuous threats from fungal pathogens, leaf rust...
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A Short Game-Based Intervention for Enhancing Executive Functions at School: a Pilot Study
Executive functions (EFs) are crucial for self-regulation, and they can explain the difficulties that many children face at school in terms of both...
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Stability of N-type inactivation and the coupling between N-type and C-type inactivation in the Aplysia Kv1 channel
The voltage-dependent potassium channels (Kv channels) show several different types of inactivation. N-type inactivation is a fast inactivating...
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Systemic interindividual DNA methylation variants in cattle share major hallmarks with those in humans
BackgroundWe recently identified ~ 10,000 correlated regions of systemic interindividual epigenetic variation (CoRSIVs) in the human genome. These...
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Gras** the big picture: impact analysis of screening tools for timely referral for device-aided therapies
Several screening tools are available to assist general neurologists in the timely identification of patients with advanced Parkinson’s disease (PD)...
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Stroke heart injury: the effect of cerebral reperfusion treatment. A 3-year retrospective study
BackgroundCardiac involvement following an acute stroke (Stroke Heart Syndrome—SHS) is an established complication and it is linked to the...
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Fluorescence Studies on the Binding Affinity and Determination of Vitamin B12 in the Presence of Fibrinogen
The binding properties between vitamin B12 (vitB12, cyanocobalamin) and fibrinogen (Fib) were investigated by UV-vis absorption and...
