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Early biomarkers in the presymptomatic phase of cognitive impairment: changes in the endocannabinoidome and serotonergic pathways in Alzheimer's-prone mice after mTBI
BackgroundDespite extensive studies on the neurobiological correlates of traumatic brain injury (TBI), little is known about its molecular...
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Automated classification of brain MRI reports using fine-tuned large language models
PurposeThis study aimed to investigate the efficacy of fine-tuned large language models (LLM) in classifying brain MRI reports into pretreatment,...
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Elucidating the therapeutic mechanism of betanin in Alzheimer’s Disease treatment through network pharmacology and bioinformatics analysis
Betanin, a natural compound with anti-inflammatory and antioxidant properties, has shown promise in mitigating Alzheimer’s disease (AD) by reducing...
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Unleashing the Neurotherapeutic Potential: The Crucial Role of miR-206-3p in Facilitating Hsp90aa1-Mediated Central Nervous System Injuries During Heat Stroke
This study aims to explore the molecular mechanisms of miR-206-3p in regulating Hsp90aa1 and its involvement in the central nervous system (CNS)...
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Dissociable functional responses along the posterior-anterior gradient of the frontal and parietal cortices revealed by parametric working memory and training
While the storage capacity is limited, accumulating studies have indicated that working memory (WM) can be improved by cognitive training. However,...
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Neuroaxonal Injury May Mediate the Association Between Hyperglycemia and Prognosis in Spontaneous Subarachnoid Hemorrhage
Hyperglycemia during early brain injury (EBI) period after spontaneous subarachnoid hemorrhage (SAH) is associated with poor outcome, but the...
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Bow hunter’s syndrome due to an anomalous right vertebral artery origin and contralateral absence: a case report and literature review
BackgroundBow Hunter’s syndrome (BHS), also known as rotational vertebral artery occlusion (RVAO), is a rare condition characterized by dynamic...
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High resolution imaging of human development: shedding light on contrast agents
BackgroundVisualizing (micro)vascular structures remains challenging for researchers and clinicians due to limitations in traditional radiological...
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Dual-task improvement of older adults after treadmill walking combined with blood flow restriction of low occlusion pressure: the effect on the heart–brain axis
ObjectiveThis study explored the impact of one session of low-pressure leg blood flow restriction (BFR) during treadmill walking on dual-task...
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Serum Erythropoietin and Ischemic-Modified Albumin Levels in Adolescents with Obsessive–Compulsive Disorder
Erythropoietin (EPO) has neuroprotective effects by increasing oxidative stress resistance and stabilizing redox balance. Ischemic-modified albumin...
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“Don’t talk to me like I am an illness”: exploring patients’ needs using the communication passport in an eating disorder service
PurposeSocial challenges are common in patients with eating disorders (ED). The presence of autistic characteristics often exacerbates social...
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Elevated serum neurofilament light chain levels are associated with hepatic encephalopathy in patients with cirrhosis
Increasing evidences implicate vital role of neuronal damage in the development of hepatic encephalopathy (HE). Neurofilament light chain (NfL) is...
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Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury
Ischemia-induced retinopathy is a hallmark finding of common visual disorders including diabetic retinopathy (DR) and central retinal artery and vein...
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Efficacy and Safety of Atogepant for Preventing Chronic and Episodic Migraines: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Purpose of ReviewCalcitonin gene-related peptide (CGRP) pathway modulators, such as atogepant, represent a novel therapeutic option for the treatment...
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Patientenbefragung zum Einsatz von Videosprechstunden in der ambulanten Behandlung von chronischem Pruritus
BackgroundAnalyses of patient evaluations and barriers to the implementation of teledermatology procedures are still rare. The aim of this study was...
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De-escalation and Discontinuation of Disease-Modifying Therapies in Multiple Sclerosis
Purpose of ReviewLong-term use of multiple sclerosis (MS) disease-modifying therapies (DMTs) is standard practice to prevent accumulation of...
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CAR-NKT Cells in Asthma: Use of NKT as a Promising Cell for CAR Therapy
NKT cells, unique lymphocytes bridging innate and adaptive immunity, offer significant potential for managing inflammatory disorders like asthma....
