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Stereotactic body radiation therapy for multiple lung cancers in a patient with six primary cancers: a case report
BackgroundSurgery is the standard care for patients with early-stage lung cancer, and stereotactic body radiation therapy is an option for those who...
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Sex-dependent association of serum vitamin D with muscle strength in older adults: NHANES 2001–2002
BackgroundAlthough several studies have suggested a potential positive association between serum vitamin D levels and muscle strength in older...
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Optimizing coronary CT angiography quality with motion-compensated reconstruction for second-generation dual-layer spectral detector CT
ObjectivesTo investigate the effect of motion-compensated reconstruction (MCR) algorithm on improving the image quality of coronary computed...
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A double CYP27A1 gene mutation in spinal cerebrotendinous xanthomatosis in a patient presenting with spastic gait: a case report
BackgroundCerebrotendinous xanthomatosis (CTX, OMIM #213700) is a rare inherited metabolic disease caused by the mutation in the CYP27A1 gene....
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The RNA helicases DDX19A/B modulate selinexor sensitivity by regulating MCL1 mRNA nuclear export in leukemia cells
Selinexor, a first-in-class exportin1 (XPO1) inhibitor, is an attractive anti-tumor agent because of its unique mechanisms of action; however, its...
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Applying a User-Centered Design Framework to Develop a Remote Research Assessment Protocol for a Randomized Clinical Trial for Toddlers with Early Autism Characteristics
COVID-19 required many research teams to shift from in-person to remote assessments, which posed both procedural and theoretical challenges. While...
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Radiomics model based on dual-energy CT can determine the source of thrombus in strokes with middle cerebral artery occlusion
PurposeTo develop thrombus radiomics models based on dual-energy CT (DECT) for predicting etiologic cause of stroke.
MethodsWe retrospectively...
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A small molecule compound targeting hemagglutinin inhibits influenza A virus and exhibits broad-spectrum antiviral activity
Influenza A virus (IAV) is a widespread pathogen that poses a significant threat to human health, causing pandemics with high mortality and...
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Minimally invasive approach in a rare emergency surgery, gallbladder perforation
BackgroundGallbladder perforations are challenging to manage for surgeons due to their high morbidity and mortality, rarity, and surgical approach....
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Spinal dementia: Don’t miss it, it’s treatable
Background & purposeAround 5% of dementia patients have a treatable cause. To estimate the prevalence of two rare diseases, in which the treatable...
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Central nervous system involvement in chronic lymphocytic leukemia: a case report and review of literature
BackgroundCentral nervous system involvement in chronic lymphocytic leukemia rarely occurs, and there is no standard therapy for central nervous...
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PICC tip dislodgement causing massive pleural effusion and atelectasis with acute respiratory failure: a case report
Peripheral intravenous central catheter (PICC) is a common tool for intravenous infusion for children who need central venous access. Although it is...
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Glycogenolysis-Induced Astrocytic Ser**1 Expression Regulates Neuroinflammatory Effects on Hippocampal neuron
The bacterial pathogen, lipopolysaccharide (LPS), elicits microglial response and induces cytokine secretion that subsequently activates astrocytes....
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Greater Self-reported Health is Associated with Lower Disgust: Evidence for Individual Calibration of the Behavioral Immune System
A key theoretical component of the behavioral immune system is its functional flexibility, where an individual’s reaction to pathogenic stimuli is...
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Conditional survival and the prognostic value of serum carcinoembryonic antigen level in oldest old with colorectal cancer
BackgroundTo evaluate the clinical value of serum CEA levels and their implications on the diagnostic value of the conventional TNM staging system in...
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Zinc finger 259 gene polymorphisms in Egyptian patients with metabolic syndrome and its association with dyslipidemia
BackgroundZinc finger protein 1 (ZPR1), encoded by the ZNF259 gene, plays crucial roles in transcriptional regulation and cell cycle progression....
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Non-surgical vs. surgical treatment of distal radius fractures: a meta-analysis of randomized controlled trials
PurposeTo compare the clinical outcomes between nonsurgical and surgical treatment of distal radius fracture.
MethodsWe performed a systematic...
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Clinical characteristics of extracorporeal cardiopulmonary resuscitation in China: a multicenter retrospective study
PurposeExtracorporeal cardiopulmonary resuscitation (ECPR) might markedly increase the survival of selected patients with refractory cardiac arrest....
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Effect of NLRP3 gene knockdown on pyroptosis and ferroptosis in diabetic cardiomyopathy injury
Diabetic cardiomyopathy (DCM) is a chronic disease caused by diabetes mellitus, which is recognized as a worldwide challenging disease. This study...
