Search
Search Results
-
Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases
Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells. Whether...
-
Hemophagocytic Lymphohistiocytosis for the Inpatient Dermatologist
Hemophagocytic lymphohistiocytosis (HLH) is a potentially life-threatening condition characterized by dysregulation of the immune system leading to...
-
Diagnostic performance of coronary calcifications on CT to rule out acute coronary syndrome in the emergency department
BackgroundAt present, the diagnosis of acute coronary syndrome (ACS) can be made by emergency physicians using the usual complementary tests, since...
-
Fragile X Syndrome and FMR1 premutation: results from a survey on associated conditions and treatment priorities in Italy
Background and objectivesFragile X Syndrome (FXS) is the most common cause of inherited intellectual disability, caused by CGG-repeat expansions...
-
Influence of prediabetes on the prognosis of patients with myocardial infarction: a meta-analysis
BackgroundPrevious studies evaluating the association between prediabetes the prognosis of patients with acute myocardial infarction (AMI) showed...
-
Effect of dipeptidyl peptidase-4 inhibitors on tumor necrosis factor alpha levels in patients with type 2 diabetes mellitus
AimsDipeptidyl peptidase-4 inhibitors (DPP-4i) served as oral antidiabetic agents for treatment of type 2 diabetes mellitus (T2DM). Although an...
-
Use of diabetes technology in children
Children with type 1 diabetes and their caregivers face numerous challenges navigating the unpredictability of this complex disease. Although the...
-
The clinical value of artificial intelligence in assisting junior radiologists in thyroid ultrasound: a multicenter prospective study from real clinical practice
BackgroundThis study is to propose a clinically applicable 2-echelon (2e) diagnostic criteria for the analysis of thyroid nodules such that low-risk...
-
Real world treatment outcomes in polypoidal choroidal vasculopathy in a Caucasian population of British ethnicity
PurposeTo assess treatment response of Polypoidal choroidal vasculopathy (PCV) in a Caucasian population of British ethnicity with intravitreal...
-
The associations between the Geriatric Nutritional Risk Index and all-cause, cancer-specific, and cardiovascular mortality in the U.S. population: a large-scale pooled survey
BackgroundPrevious studies have reported a close association between the Geriatric Nutritional Risk Index (GNRI) and various conditions. However, the...
-
Sodium tanshinone IIA sulfonate protects vascular relaxation in ApoE-knockout mice by inhibiting the SYK-NLRP3 inflammasome-MMP2/9 pathway
BackgroundHyperlipidemia damages vascular wall and serves as a foundation for diseases such as atherosclerosis, hypertension and stiffness. The...
-
Does metformin really reduce prostate cancer risk: an up-to-date comprehensive genome-wide analysis
BackgroundThe relationship between metformin use and prostate cancer (PCa) risk has yet to be clear despite more than a decade of debate on this...
-
-
Development and preliminary evaluation of a suicidal risk assessment protocol in a randomised controlled trial using the Patient Health Questionnaire (PHQ-9)
BackgroundParticipants in research trials often disclose severe depression symptoms, including thoughts of self-harm and suicidal ideation, in...
-
Elucidating the therapeutic mechanism of betanin in Alzheimer’s Disease treatment through network pharmacology and bioinformatics analysis
Betanin, a natural compound with anti-inflammatory and antioxidant properties, has shown promise in mitigating Alzheimer’s disease (AD) by reducing...
-
Evolution of hadron therapy from 1935 to 2005: a personal view
IntroductionHadron therapy is today an established modality in cancer radiation therapy that, world-wide, is available in about hundred centres....
-
Nuclear alpha-synuclein accelerates cell senescence and neurodegeneration
BackgroundThe progression of Parkinson’s disease (PD) is related to ageing. The accumulation of nuclear alpha-synuclein (α-syn) may accelerate the...
-
eHSP90α in front-line therapy in EGFR exon 19 deletion and 21 Leu858Arg mutations in advanced lung adenocarcinoma
PurposeExtracellular heat shock protein 90 AA1(eHSP90α) is intricately linked to tumor progression and prognosis. This study aimed to investigate the...
