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Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition
SF3B1 mutations frequently occur in cancer yet lack targeted therapies. Clinical trials of XPO1 inhibitors, selinexor and eltanexor, in high-risk...
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Doing a double take: when transthoracic echocardiography fails for mitral valve annuloplasty ring endocarditis with Streptococcus pyogenes: a case report
BackgroundThis case highlights several complications of a late and rare presentation of culture-negative Streptococcus pyogenes endocarditis of a...
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Effectiveness of synthetic versus autologous bone grafts in foot and ankle surgery: a systematic review and meta-analysis
BackgroundAll orthopaedic procedures, comprising foot and ankle surgeries, seemed to show a positive trend, recently. Bone grafts are commonly...
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Dietary salt promotes cognitive impairment through repression of SIRT3/PINK1-mediated mitophagy and fission
Dietary salt is increasingly recognized as an independent risk factor for cognitive impairment. However, the exact mechanisms are not yet fully...
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Diffusion-tensor magnetic resonance imaging as a non-invasive assessment of extracellular matrix remodeling in lumbar paravertebral muscles of rats with sarcopenia
BackgroundExtracellular matrix (ECM) remodeling in skeletal muscle is a significant factor in the development of sarcopenia. This study aims to...
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Analysis of Oncology and Radiation Therapy Representation on the National Board of Medical Examiners Official Practice Material for the United States National Standardized Medical Board Examinations
Radiation therapy (RT) is a critical component of multidisciplinary cancer care, but has inconsistent curricular exposure. We characterize the...
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Inhibitors of apolipoprotein C3, triglyceride levels, and risk of pancreatitis: a systematic review and meta-analysis
In recent years, novel apoC3 inhibitor therapies for the treatment of hypertriglyceridemia have been developed and assessed through phase II and III...
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Emerging biologic augmentation strategies for meniscal repair: a systematic review
BackgroundMeniscal repair should be the gold standard. However, the meniscus is poorly vascularized and even an excellent meniscus repair may not...
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Multiple lung abscesses and cold agglutinin syndrome following coronavirus disease 2019: a case report
BackgroundCold agglutination syndrome is a subtype of autoimmune hemolytic anemia. The condition is referred to as “cold” because the antibodies...
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Lnc PVT1 facilitates TGF-β1-induced human cardiac fibroblast activation in vitro and ISO-induced myocardial fibrosis in vivo through regulating MYC
Cardiac fibrosis is a commonly seen pathophysiological process in various cardiovascular disorders, such as coronary heart disorder, hypertension,...
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The effect of cesarean delivery on the neonatal gut microbiome in an under-resourced population in the Bronx, NY, USA
BackgroundNeonatal and early-life gut microbiome changes are associated with altered cardiometabolic and immune development. In this study, we...
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Investigating distinct clinical features and constructing a nomogram model for survival probability in adults with cerebellar high-grade gliomas
BackgroundThe clinical features of cerebellar high-grade gliomas (cHGGs) in adults have not been thoroughly explored. This large-scale,...
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Targeting CD73 limits tumor progression and enhances anti-tumor activity of anti-PD-1 therapy in intrahepatic cholangiocarcinoma
Background & aimsPatients with intrahepatic cholangiocarcinoma (iCCA) respond poorly to immune checkpoint blockades (ICBs). In this study, we aimed...
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RET Inhibitors in RET Fusion-Positive Lung Cancers: Past, Present, and Future
While activating RET fusions are identified in various cancers, lung cancer represents the most common RET fusion-positive tumor. The clinical drug...
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Clinical outcomes of carbapenem-resistant gram-negative bacterial bloodstream infection in patients with end-stage renal disease in intensive care units: a multicenter retrospective observational study
BackgroundCarbapenem-resistant gram-negative bacteria (CRGNB) present a considerable global threat due to their challenging treatment and increased...
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Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases
Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells. Whether...
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Effect of dipeptidyl peptidase-4 inhibitors on tumor necrosis factor alpha levels in patients with type 2 diabetes mellitus
AimsDipeptidyl peptidase-4 inhibitors (DPP-4i) served as oral antidiabetic agents for treatment of type 2 diabetes mellitus (T2DM). Although an...
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An elderly case of paraneoplastic anti-NMDA receptor encephalitis associated with large cell neuroendocrine carcinoma of the lung
BackgroundRecent studies have suggested that N-methyl-D-aspartate (NMDA) receptors are involved in the cell proliferation in several tumors. However,...
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Use of diabetes technology in children
Children with type 1 diabetes and their caregivers face numerous challenges navigating the unpredictability of this complex disease. Although the...