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Identification of volatile metabolites produced from levodopa metabolism by different bacteria strains of the gut microbiome
Interspecies pathways in the gut microbiome have been shown to metabolize levodopa, the primary treatment for Parkinson’s disease, and reduce its...
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C4-like Sesuvium sesuvioides (Aizoaceae) exhibits CAM in cotyledons and putative C4-like + CAM metabolism in adult leaves as revealed by transcriptome analysis
BackgroundThe co-occurrence of C 4 and CAM photosynthesis in a single species seems to be unusual and rare. This is likely due to the difficulty in...
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Preclinical and clinical advances to overcome hypoxia in glioblastoma multiforme
Glioblastoma multiforme (GBM) is the most common adult primary brain tumor. The standard clinical treatment of GBM includes a maximal surgical...
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Age-related dysregulation of CXCL9/10 in monocytes is linked to impaired innate immune responses in a mouse model of Staphylococcus aureus osteomyelitis
BackgroundAge-associated impairments in innate immunity are believed to be a causative factor responsible for severe pathogenesis of Staphylococcus...
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A novel deep-benthic sea cucumber species of Benthodytes (Holothuroidea, Elasipodida, Psychropotidae) and its comprehensive mitochondrial genome sequencing and evolutionary analysis
BackgroundThe holothurians, commonly known as sea cucumbers, are marine organisms that possess significant dietary, nutritional, and medicinal value....
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Biogeographical distribution and community assembly of Myxococcota in mangrove sediments
BackgroundMyxococcota, characterized by their distinct social lifestyles, are widely distributed micro-predators in global sediments. They can feed...
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CRISPR screens in 3D tumourspheres identified miR-4787-3p as a transcriptional start site miRNA essential for breast tumour-initiating cell growth
Our study employs pooled CRISPR screens, integrating 2D and 3D culture models, to identify miRNAs critical in Breast Cancer (BC) tumoursphere...
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GPR116 alleviates acetaminophen-induced liver injury in mice by inhibiting endoplasmic reticulum stress
BackgroundAcetaminophen (APAP) overdose is a significant contributor to drug-induced liver injury worldwide. G-protein–coupled receptor 116 (GPR116)...
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Dietary silymarin improves performance by altering hepatic lipid metabolism and cecal microbiota function and its metabolites in late laying hens
BackgroundLiver lipid dysregulation is one of the major factors in the decline of production performance in late-stage laying hens. Silymarin (SIL),...
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The eEF2 kinase coordinates the DNA damage response to cisplatin by supporting p53 activation
Eukaryotic elongation factor 2 (eEF2) kinase (eEF2K) is a stress-responsive hub that inhibits the translation elongation factor eEF2, and...
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Multicenter proteome-wide Mendelian randomization study identifies causal plasma proteins in melanoma and non-melanoma skin cancers
This study addresses the diagnostic and therapeutic challenges in malignant melanoma (MM) and non-melanoma skin cancers (NMSC). We aim to identify...
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IL-4/IL-4R axis signaling drives resistance to immunotherapy by inducing the upregulation of Fcγ receptor IIB in M2 macrophages
In recent years, immunotherapy, particularly PD-1 antibodies, have significantly enhanced the outcome of gastric cancer patients. Despite these...
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Biochemical characterisation and production kinetics of high molecular-weight (HMW) putative antibacterial proteins of insect pathogenic Brevibacillus laterosporus isolates
BackgroundBacterial genomes often encode structures similar to phage capsids (encapsulins) and phage tails which can be induced spontaneously or...
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The ubiquitin-like protein UBTD1 promotes colorectal cancer progression by stabilizing c-Myc to upregulate glycolysis
Dysfunction of the ubiquitin-proteasome system (UPS) is involved in the pathogenesis of various malignancies including colorectal cancer (CRC)....
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Repurposing Type I-A CRISPR-Cas3 for a robust diagnosis of human papillomavirus (HPV)
R-loop-triggered collateral single-stranded DNA (ssDNA) nuclease activity within Class 1 Type I CRISPR-Cas systems holds immense potential for...
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Deep metagenomic sequencing unveils novel SAR202 lineages and their vertical adaptation in the ocean
SAR202 bacteria in the Chloroflexota phylum are abundant and widely distributed in the ocean. Their genome coding capacities indicate their potential...
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Delineating the response of antioxidant enzymes comparatively in four guar genotypes under drought stress
Antioxidant responses play a crucial role in combating free radical damage induced by drought stress. In guar plants, the antioxidant mechanism is...
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The excito-repellent activity of five essential oils extracted from local plants against dengue and malaria vectors in Burkina Faso
Using chemical insecticides remains the main way to prevent and manage dengue and malaria, two main mosquito-borne diseases. However, the vectors of...
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First Report of Bothynus striatellus (Coleoptera: Melolonthidae) Damaging Lucerne Crops in Argentina
We report for the first time that larvae of the genus Bothynus Hope (Coleoptera: Melolonthidae) caused economic damage to lucerne ( Medicago sativa ...
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Exploring the influence of rapeseed cultivar and pathogen isolate on Acremonium alternatum's efficacy in clubroot disease control
Clubroot disease, caused by Plasmodiophora brassicae , ranks among the most significant diseases affecting rapeseed cultivars, leading to substantial...
