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SUMOylation of nuclear receptor Nor1/NR4A3 coordinates microtubule cytoskeletal dynamics and stability in neuronal cells
BackgroundNor1/NR4A3 is a member of the NR4A subfamily of nuclear receptors that play essential roles in regulating gene expression related to...
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The role of quercetin in ameliorating bleomycin-induced pulmonary fibrosis: insights into autophagy and the SIRT1/AMPK signaling pathway
BackgroundIdiopathic pulmonary fibrosis (IPF) is a disease of unknown etiology characterized by a constant incidence rate. Unfortunately, effective...
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A biochemical assessment of apoptosis-inducing impact of Salinomycin in combination with ciprofloxacin on human leukemia KG1–a stem-like cells in the presence and absence of insulin
BackgroundAcute Myeloid Leukemia (AML) is a fast-develo** invading cancer that impacts the blood and bone marrow, marked by the rapid proliferation...
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Advances in development of biomarkers for brain damage and ischemia
Acquired brain injury is an urgent situation that requires rapid diagnosis and treatment. Magnetic resonance imaging (MRI) and computed tomography...
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Where do Harris’ Checkerspots Lay their Eggs and what are the Consequences?
Where a female lays her eggs has strong implications for the survival of her offspring, an impetus that takes on particular significance for species...
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Multiplex PCR-based genoty** of Salmonella Enteritidis and Salmonella Typhimurium from food sources and assessment of their antimicrobial resistance profiles in Egypt
BackgroundSalmonellosis is a widespread zoonotic disease that poses a significant threat to livestock and public health. This study aimed to serotype...
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Suppression of CTC1 inhibits hepatocellular carcinoma cell growth and enhances RHPS4 cytotoxicity
BackgroundAlthough DNA repair mechanisms function to maintain genomic integrity, in cancer cells these mechanisms may negatively affect treatment...
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SWI/SNF Complex Connects Signaling and Epigenetic State in Cells of Nervous System
SWI/SNF protein complexes are evolutionarily conserved epigenetic regulators described in all eukaryotes. In metameric animals, the complexes are...
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Association of histidine-rich glycoprotein C633T single nucleotide polymorphism and recurrent miscarriage in Iranian women
BackgroundRecurrent miscarriage (RM) is defined as the occurrence of at least two or three subsequent miscarriages within the 20th -24th weeks of...
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Immunodetection of tubulin and centromeric histone H3 (CENH3) proteins in Glycine species
BackgroundThe centromeres appear as primary constrictions on monocentric metaphase chromosomes; where sister chromatids are held together and...
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Nerve Regeneration Through Differentiation of Endometrial-Derived Mesenchymal Stem Cells into Nerve-Like Cells Using Polyacrylonitrile/Chitosan Conduit and Berberine in a Rat Sciatic Nerve Injury Model
Nervous injuries are common in humans. One of the most advanced treatment methods is neural tissue engineering. This research aims to utilize...
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Loop-mediated isothermal amplification (LAMP) assay for early on-site detection of Group B Streptococcus infection in neonatal sepsis blood sample
BackgroundNeonatal sepsis, often attributed to Group B Streptococcus (GBS) infection, poses a critical health risk to infants, demanding rapid and...
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Evaluating the expression pattern of ATXN1 and CDC42EP1 genes and related long noncoding RNAs in oral squamous cell carcinoma
BackgroundOral squamous cell carcinoma (OSCC) is a significant health issue worldwide, and the expression of long non-coding RNAs (lncRNAs) are...
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Molecular identification and GC-MS analysis of a newly isolated novel bacterium (Lysinibacillus sp. VCRC B655) for mosquito control
BackgroundMosquitoes are widespread globally and have contributed to transmitting pathogens to humans and the burden of vector-borne diseases. They...
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β-Hydroxybutyrate and melatonin suppress maladaptive UPR, excessive autophagy and pyroptosis in Aβ 1–42 and LPS-Induced SH-SY5Y cells
BackgroundAlzheimer’s disease is a neurological disease characterized by the build-up of amyloid beta peptide (Aβ) and lipopolysaccharide (LPS),...
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Up-regulation of miR-126 via DNA methylation in hypoxia-preconditioned endothelial cells may contribute to hypoxic tolerance of neuronal cells
BackgroundEndothelial cells (ECs) can confer neuroprotection by secreting molecules. This study aimed to investigate whether DNA methylation...
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Regulation of MicroRNA-4697-3p by Parkinson’s disease-associated SNP rs329648 and its impact on SNCA112 mRNA
BackgroundParkinson’s disease (PD) is a common neurodegenerative disorder characterized by a multifaceted genetic foundation. Genome-Wide Association...
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Genetic components of microdeletion syndromes and their role in determining schizophrenia traits
Schizophrenia is a neuropsychiatric disorder characterized by various symptoms such as hallucinations, delusions, and disordered thinking. The...
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Assessment of ID family proteins expression in colorectal cancer of Iraqi patients
BackgroundColorectal cancer (CRC) is the second most deathly worldwide and third most common cancer, CRC is a very heterogeneous disease where tumors...
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Research progress on differentiation and regulation of plant chromoplasts
Carotenoids, natural tetraterpenoids found abundantly in plants, contribute to the diverse colors of plant non-photosynthetic tissues and provide...
