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Corticosteroids are still first-line therapies for bullous pemphigoid, with biologics finding use in difficult-to-treat disease
Bullous pemphigoid is an autoantibody-mediated subepidermal blistering disorder which develops predominately in patients of advanced age....
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Advances in the anti-tumor mechanisms of saikosaponin D
Saikosaponin D, a saponin compound, is extracted from Bupleurum and is a principal active component of the plant. It boasts a variety of...
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Efficiency of eSource Direct Data Capture in Investigator-Initiated Clinical Trials in Oncology
BackgroundClinical trials have become larger and more complex. Thus, eSource should be used to enhance efficiency. This study aimed to evaluate the...
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Research progress of propofol in alleviating cerebral ischemia/reperfusion injury
Ischemic stroke is a leading cause of adult disability and death worldwide. The primary treatment for cerebral ischemia patients is to restore blood...
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Adis summary of research: Matching‑adjusted indirect comparisons of diroximel fumarate, ponesimod, and teriflunomide for relapsing multiple sclerosis
Several oral disease-modifying therapies (DMTs) have been approved for the treatment of relapsing multiple sclerosis (MS), including diroximel...
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Mutagenic Azido Impurities in Drug Substances: A Perspective
Contamination of drug products and substances containing impurities is a significant concern in the pharmaceutical industry because it may impact the...
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Adis summary of research: A 10-year observational study of the use, acceptability and effectiveness of long-acting paliperidone palmitate: implications for clinical decision making
Atypical long-acting injectable antipsychotics, such as paliperidone palmitate, play an important role in the management of psychotic disorders. They...
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Can probiotics be used in the prevention and treatment of bronchial asthma?
Asthma is a lifelong condition with varying degrees of severity and susceptibility to symptom control. Recent studies have examined the effects of...
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Interactions between metabotropic glutamate and CB1 receptors: implications for mood, cognition, and synaptic signaling based on data from mGluR and CB1R-targeting drugs
Metabotropic glutamate receptors (mGluRs) are part of the G protein-coupled receptors (GPCRs) family. They are coupled to G αq (group I) or G i/o ...
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Map** Cutaneous Tissue Distribution of Sesquiterpene Lactone Goyazensolide Using MALDI Imaging
Species of Lychnophora , popularly known in Brazil as “arnica-da-serra,” are widely used in topical preparations as analgesics and...
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Adis summary of research: Safety, tolerability and pharmacokinetics of aripiprazole 2-monthly formulation in patients with schizophrenia or bipolar I disorder
The once-monthly long-acting injectable (LAI) formulation of aripiprazole, an atypical antipsychotic that stabilizes the dopamine-serotonin system,...
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Mechanistic insights on TLR-4 mediated inflammatory pathway in neurodegenerative diseases
Neurodegenerative diseases (NDDs) pose a significant issue in healthcare, needing a thorough knowledge of their complex molecular mechanisms. A...
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A derivative of 3-(1,3-diarylallylidene)oxindoles inhibits dextran sulfate sodium-induced colitis in mice
BackgroundIA-0130 is a derivative of 3-(1,3-diarylallylidene)oxindoles, which is a selective estrogen receptor modulator (SERM). A previous study...
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Investigation of the Antinociceptive and Gastroprotective Potential of the Flavonoid Tricin and its Possible Mechanism of Action
Tricin is a flavonoid that occurs in monocotyledonous plants and exhibits a broad pharmacological spectrum, including anti-inflammatory and...
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Qualitative Analysis of Inquiries Received by FDA Regarding Conduct of Clinical Trials during the Covid-19 Public Health Emergency
BackgroundThis report describes the U.S. Food and Drug Administration (FDA) experience in establishing a dedicated mailbox, and in publishing related...
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Multi-layered metabolic effects of trehalose on the liver proteome in apoE-knockout mice model of liver steatosis
BackgroundMetabolic dysfunction-associated fatty liver disease has been well documented as a key independent risk factor for the development of...
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Use of Seamless Study Designs in Oncology Clinical Development– A Survey Conducted by IDSWG Oncology Sub-team
Seamless study designs have the potential to accelerate clinical development. The use of innovative seamless designs has been increasing in the...
