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DNA Methylation-derived biological age and long-term mortality risk in subjects with type 2 diabetes
BackgroundIndividuals with type 2 diabetes (T2D) face an increased mortality risk, not fully captured by canonical risk factors. Biological age...
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Heart rate variability as a predictor of intraoperative autonomic nervous system homeostasis
The aim of the proof-of-concept study is to investigate the level of concordance between the heart rate variability (HRV), the EEG-based Narcotrend...
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Predictive enrichment for the need of renal replacement in sepsis-associated acute kidney injury: combination of furosemide stress test and urinary biomarkers TIMP-2 and IGFBP-7
BackgroundIn sepsis, initial resuscitation with fluids is followed by efforts to achieve a negative fluid balance. However, patients with...
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Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition
SF3B1 mutations frequently occur in cancer yet lack targeted therapies. Clinical trials of XPO1 inhibitors, selinexor and eltanexor, in high-risk...
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Relationship between the severity of functional mitral regurgitation at admission and one-year outcomes in patients hospitalized for acute heart failure with mildly reduced ejection fraction
BackgroundThe epidemiological distribution of functional mitral regurgitation (FMR) in heart failure (HF) and mildly reduced ejection fraction...
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Breathing difficulties in a nonagenarian: a self report
This is a self report. It is age related because I am 96 years old; about 5 years ago I was asymptomatic in this respect. I describe the difficulties...
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Enhancing sepsis biomarker development: key considerations from public and private perspectives
Implementation of biomarkers in sepsis and septic shock in emergency situations, remains highly challenging. This viewpoint arose from a...
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Enhancing patient acceptance of ICD implantation through structured shared decision making: conversation is key
BackgroundImplantable cardioverter-defibrillators (ICDs) and cardiac resynchronization therapy defibrillators (CRT-D) are lifesaving treatments for...
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Application of a Novel Mitral Valvuloplasty Strategy in Children with Mitral Regurgitation
To retrospectively analyze the clinical efficacy of an innovative mitral valvuloplasty strategy in the treatment of mitral regurgitation in children....
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Magnitude of emergence agitation, its interventions and associated factors among paediatric surgical patients
BackgroundEmergence agitation is a transient confusional state of a child associated with consciousness from general anaesthesia, commonly occurs in...
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Targeting CERS6-AS1/FGFR1 axis as synthetic vulnerability to constrain stromal cells supported proliferation in Mantle cell lymphoma
The interaction between stromal and tumor cells in tumor microenvironment is a crucial factor in Mantle cell lymphoma (MCL) progression and therapy...
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Lecithin and cardiovascular health: a comprehensive review
BackgroundCardiovascular diseases are one of the prime causes of mortality globally. Therefore, concerted efforts are made to prevent or manage...
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Interatrial Communications: Prevalence and Subtypes in 12,385 Newborns–a Copenhagen Baby Heart Study
The prevalence of interatrial communications in newborns, i.e., patent foramen ovale or atrial septal defect, was previously reported to be between...
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Uric acid to albumin ratio as a novel predictor for coronary slow flow phenomenon in patients with chronic coronary syndrome and non-obstructive coronary arteries
BackgroundThe plasma uric acid to albumin ratio (UAR) is considered as a novel indicator for Inflammation. However, the association between UAR and...
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Next-generation atrial fibrillation ablation: clinical performance of pulsed-field ablation and very high-power short-duration radiofrequency
IntroductionPulsed-field energy (PFA) and very high-power short-duration radiofrequency (vHPSD-RF) are two novel ablation methods for pulmonary vein...
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Comprehensive analysis of the association between triglyceride-glucose index and coronary artery disease severity across different glucose metabolism states: a large-scale cross-sectional study from an Asian cohort
BackgroundThe triglyceride-glucose (TyG) index is associated with the development and prognosis of coronary artery disease (CAD). However, the impact...
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Sodium tanshinone IIA sulfonate protects vascular relaxation in ApoE-knockout mice by inhibiting the SYK-NLRP3 inflammasome-MMP2/9 pathway
BackgroundHyperlipidemia damages vascular wall and serves as a foundation for diseases such as atherosclerosis, hypertension and stiffness. The...
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An elderly case of paraneoplastic anti-NMDA receptor encephalitis associated with large cell neuroendocrine carcinoma of the lung
BackgroundRecent studies have suggested that N-methyl-D-aspartate (NMDA) receptors are involved in the cell proliferation in several tumors. However,...
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Trace of delirium after robotic lower abdominal tumor resection at different end-tidal carbon dioxide: a RCT trial
BackgroundPostoperative delirium (POD) often occurs in oncology patients, further increasing the medical and financial burden. Robotic technology in...
