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The risks for major psychiatric disorders in the siblings of probands with major depressive disorder
Using a case-controlled study including siblings of major depression (MD) and control probands, born 1970–1990 and followed through 2018, we sought...
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Thalamocortical functional connectivity and rapid antidepressant and antisuicidal effects of low-dose ketamine infusion among patients with treatment-resistant depression
Previous studies have shown an association between the thalamocortical dysconnectivity and treatment-resistant depression (TRD). Whether a single...
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Effects of psychedelic, DOI, on nucleus accumbens dopamine signaling to predictable rewards and cues in rats
Psychedelics produce lasting therapeutic responses in neuropsychiatric diseases suggesting they may disrupt entrenched associations and catalyze...
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Serotonergic psychedelic 5-MeO-DMT alters plasticity-related gene expression and generates anxiolytic effects in stressed mice
Serotonergic psychedelics have potential therapeutic effects in treating anxiety and mood disorders, often after a single dose, and are suggested to...
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Is depression a global brain disorder with topographic dynamic reorganization?
Major depressive disorder (MDD) is characterized by a multitude of psychopathological symptoms including affective, cognitive, perceptual,...
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The parasubthalamic nucleus refeeding ensemble delays feeding initiation and hastens water drinking
The parasubthalamic nucleus (PSTN) is activated by refeeding after food deprivation and several PSTN subpopulations have been shown to suppress...
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From movement to motivation: a proposed framework to understand the antidepressant effect of exercise
Depression is the leading cause of disability worldwide, exerting a profound negative impact on quality of life in those who experience it....
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Neuroimaging and natural language processing-based classification of suicidal thoughts in major depressive disorder
Suicide is a growing public health problem around the world. The most important risk factor for suicide is underlying psychiatric illness, especially...
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Des-acyl ghrelin reduces alcohol intake and alcohol-induced reward in rodents
The mechanisms contributing to alcohol use disorder (AUD) are complex and the orexigenic peptide ghrelin, which enhances alcohol reward, is implied...
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Vitamin D, chronic pain, and depression: linear and non-linear Mendelian randomization analyses
Vitamin D deficiency has been linked to various chronic pain conditions. However, randomized trials of vitamin D supplementation have had mixed...
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Epigenetic signals associated with delirium replicated across four independent cohorts
Delirium is risky and indicates poor outcomes for patients. Therefore, it is crucial to create an effective delirium detection method. However, the...
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Gestational valproic acid exposure enhances facial stimulation-evoked cerebellar mossy fiber-granule cell transmission via GluN2A subunit-containing NMDA receptor in offspring mice
Valproic acid (VPA) is one of the most effective antiepileptic drugs, and exposing animals to VPA during gestation has been used as a model for...
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Influenza A virus during pregnancy disrupts maternal intestinal immunity and fetal cortical development in a dose- and time-dependent manner
Epidemiological studies link exposure to viral infection during pregnancy, including influenza A virus (IAV) infection, with increased incidence of...
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Genetic analyses point to alterations in immune-related pathways underpinning the association between psychiatric disorders and COVID-19
Current literature suggests that people with psychiatric disorders have a higher risk of COVID-19 infection and a worse prognosis of the disease. We...
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Neuroglia in cognitive reserve
The concept of cognitive reserve was born to account for the disjunction between the objective extent of brain damage in pathology and its clinical...
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A discrete subpopulation of PFC-LHb neurons govern cocaine place preference
Addiction is a complex behavioral disorder characterized by compulsive drug-seeking and drug use despite harmful consequences. The prefrontal cortex...
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The impact of REM sleep loss on human brain connectivity
Brain function is vulnerable to the consequences of inadequate sleep, an adverse trend that is increasingly prevalent. The REM sleep phase has been...
