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The clinical value of artificial intelligence in assisting junior radiologists in thyroid ultrasound: a multicenter prospective study from real clinical practice
BackgroundThis study is to propose a clinically applicable 2-echelon (2e) diagnostic criteria for the analysis of thyroid nodules such that low-risk...
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Real world treatment outcomes in polypoidal choroidal vasculopathy in a Caucasian population of British ethnicity
PurposeTo assess treatment response of Polypoidal choroidal vasculopathy (PCV) in a Caucasian population of British ethnicity with intravitreal...
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Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases
Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells. Whether...
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Hemophagocytic Lymphohistiocytosis for the Inpatient Dermatologist
Hemophagocytic lymphohistiocytosis (HLH) is a potentially life-threatening condition characterized by dysregulation of the immune system leading to...
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Sodium tanshinone IIA sulfonate protects vascular relaxation in ApoE-knockout mice by inhibiting the SYK-NLRP3 inflammasome-MMP2/9 pathway
BackgroundHyperlipidemia damages vascular wall and serves as a foundation for diseases such as atherosclerosis, hypertension and stiffness. The...
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Effect of dipeptidyl peptidase-4 inhibitors on tumor necrosis factor alpha levels in patients with type 2 diabetes mellitus
AimsDipeptidyl peptidase-4 inhibitors (DPP-4i) served as oral antidiabetic agents for treatment of type 2 diabetes mellitus (T2DM). Although an...
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Diagnostic performance of coronary calcifications on CT to rule out acute coronary syndrome in the emergency department
BackgroundAt present, the diagnosis of acute coronary syndrome (ACS) can be made by emergency physicians using the usual complementary tests, since...
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Fragile X Syndrome and FMR1 premutation: results from a survey on associated conditions and treatment priorities in Italy
Background and objectivesFragile X Syndrome (FXS) is the most common cause of inherited intellectual disability, caused by CGG-repeat expansions...
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Exploring paramedics’ lived experiences in confrontation with patients’ death during missions: a phenomenological study
BackgroundEmergency personnel are the first line of emergency response systems to respond to emergencies; in essence, they are usually exposed to a...
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Improving the introduction of telemedicine in pre-hospital emergency medicine: understanding users and how acceptability, usability and effectiveness influence this process
IntroductionIncreasing numbers of ambulance calls, vacant positions and growing workloads in Emergency Medicine (EM) are increasing the pressure to...
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Mucinous tubular and spindle renal cell carcinoma revealed by a trauma of the kidney: a case report
BackgroundMucinous tubular and spindle cell carcinoma is a rare renal tumor. It has been recognized as a distinct entity in the 2004 World Health...
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Non-emergency department (ED) interventions to reduce ED utilization: a sco** review
BackgroundEmergency department (ED) crowding is a global burden. Interventions to reduce ED utilization have been widely discussed in the literature,...
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Woven coronary artery with acquired etiology: the natural history documented by serial angiography and optical coherence tomography
Woven coronary artery (WCA) is a rare anomaly and its etiology remains speculative. Both congenital and acquired factors are considered to be...
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Exploring the inverse relationship between serum total bilirubin and systemic immune-inflammation index: insights from NHANES data (2009–2018)
BackgroundBilirubin is known for its multifaceted attributes, including antioxidant, anti-inflammatory, immunomodulatory, and antiapoptotic...
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A cognitive-behavioral treatment for suicide prevention among adults with schizophrenia spectrum disorders in community mental health: Study protocol for a pilot feasibility and acceptability randomized clinical trial
BackgroundSuicide is among the leading causes of death for adults with schizophrenia spectrum disorders (SSDs), and there is a paucity of...
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A randomized controlled trial to assess if changing sleep timing can improve glucose metabolism in people with prediabetes and type 2 diabetes
BackgroundSocial jetlag is a chronic disruption of sleep timing that is characterized by different sleep timing during workdays and free days. Social...
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Healthcare delivery to patients from culturally and linguistically diverse backgrounds in emergency care: a sco** review protocol
BackgroundWorldwide, the culturally and linguistically diverse (CALD) population is increasing, and is predicted to reach 405 million by 2050. The...
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Advancements in differentiation between sperm cells and epithelial cells for efficient forensic DNA analysis in sexual assault cases
Most of the sexual assault casework samples are of mixed sources. Forensic DNA laboratories are always in the requirement of a precise technique for...
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Bezold’s abscess, an uncommon complication of otitis media and cholesteatoma: a case report
BackgroundMastoiditis frequently occurs in children as they are more susceptible to middle ear infections, but infrequently occurs in adults. A rare...
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Initial surgery for spontaneous intestinal perforation in extremely low birth weight infants is not associated with mortality or in-hospital morbidities
ObjectiveDetermine short-term outcomes following peritoneal drain (PD), laparotomy (LAP) after PD (PD-LAP), and LAP in extremely low birth weight...