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An ‘activator-repressor’ loop controls the anthocyanin biosynthesis in red-skinned pear
The color of red-skinned pear ( Pyrus spp.) is primarily attributed to accumulation of anthocyanins, which provide nutritional benefits for human...
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D-limonene supplementation does not alter postprandial metabolism of postmenopausal women challenged with a mixed macronutrient tolerance test: a pilot study
The hormonal decline during menopause increases women's risk of chronic diseases. D-limonene, a monoterpene found in the human diet, possesses...
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Extant and extinct bilby genomes combined with Indigenous knowledge improve conservation of a unique Australian marsupial
Ninu (greater bilby, Macrotis lagotis ) are desert-dwelling, culturally and ecologically important marsupials. In collaboration with Indigenous...
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Early detection of breast cancer through the diagnosis of Nipple Aspirate Fluid (NAF)
The development of breast cancer has been mainly reported in women who have reached the post-menopausal stage; therefore, it is the primary factor...
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Mechanisms contributing to inhibition of retinal ganglion cell death by cell permeable peptain-1 under glaucomatous stress
This study assesses the neuroprotective potential of CPP-P1, a conjugate of an anti-apoptotic peptain-1 (P1) and a cell-penetrating peptide (CPP) in...
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Exploring oak processionary caterpillar induced lepidopterism (part 2): ex vivo bio-assays unmask the role of TRPV1
As human skin comes into contact with the tiny hairs or setae of the oak processionary caterpillar, Thaumetopoea processionea , a silent yet intense...
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Sex and caste effects on the vibrational sensitivity in honey bees (Apis mellifera)
In the darkness of their nests, most social insect species communicate relying on chemical, tactile, electrical and mechanical signals. In honeybees,...
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Leading Edge Techniques in the Quest for Characterizing Rare Hematopoietic Stem Cells
Purpose of ReviewHematopoietic stem cells (HSCs) occupy the summit of the intricate hematopoiesis hierarchy, constituting a mere 0.01% of the adult...
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Transcriptome profiling of fast/glycolytic and slow/oxidative muscle fibers in aging and obesity
Aging and obesity pose significant threats to public health and are major contributors to muscle atrophy. The trends in muscle fiber types under...
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Computational approaches identify a transcriptomic fingerprint of drug-induced structural cardiotoxicity
Structural cardiotoxicity (SCT) presents a high-impact risk that is poorly tolerated in drug discovery unless significant benefit is anticipated....
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Genome-wide association analysis identify candidate genes for feed efficiency and growth traits in Wenchang chickens
BackgroundWenchang chickens are one of the most popular local chicken breeds in the Chinese chicken industry. However, the low feed efficiency is the...
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Impact of periodontal disease on cognitive disorders, dementia, and depression: a systematic review and meta-analysis
A growing body of research suggested that there was a link between poor periodontal health and systemic diseases, particularly with the early...
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Single-cell transcriptional profiling of clear cell renal cell carcinoma reveals a tumor-associated endothelial tip cell phenotype
Clear cell renal cell carcinoma (ccRCC) is the most prevalent form of renal cancer, accounting for over 75% of cases. The asymptomatic nature of the...
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A specific super-enhancer actuated by berberine regulates EGFR-mediated RAS–RAF1–MEK1/2–ERK1/2 pathway to induce nasopharyngeal carcinoma autophagy
Nasopharyngeal carcinoma (NPC), primarily found in the southern region of China, is a malignant tumor known for its highly metastatic...
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Spatially resolved epigenome sequencing via Tn5 transposition and deterministic DNA barcoding in tissue
Spatial epigenetic map** of tissues enables the study of gene regulation programs and cellular functions with the dependency on their local tissue...
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Impact of Plant Density and Irrigation Regimes on Physiological and Biochemical Responses of Cumin (Cuminum cyminum)
Cumin ( Cuminum cyminum L.) is a medicinal plant, and its quality and quantity are notably affected by agricultural practices such as plant density...
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Humanin activates integrin αV–TGFβ axis and leads to glioblastoma progression
The role of mitochondria peptides in the spreading of glioblastoma remains poorly understood. In this study, we investigated the mechanism underlying...
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The effects of Quercetin on wound healing in the human umbilical vein endothelial cells
An injury that affects the integrity of the skin, either inside or externally, is called a wound. Damaged tissue is repaired by a set of cellular and...
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A broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drug
SARS-CoV-2 infection is initiated by Spike glycoprotein binding to the human angiotensin-converting enzyme 2 (ACE2) receptor via its receptor binding...
