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Imprinted DNA methylation of the H19 ICR is established and maintained in vivo in the absence of Kaiso
BackgroundPaternal allele-specific DNA methylation of the imprinting control region ( H19 ICR) controls genomic imprinting at the Igf2/H19 locus. We...
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Native and tagged CENP-A histones are functionally inequivalent
BackgroundOver the past several decades, the use of biochemical and fluorescent tags has elucidated mechanistic and cytological processes that would...
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From compartments to loops: understanding the unique chromatin organization in neuronal cells
The three-dimensional organization of the genome plays a central role in the regulation of cellular functions, particularly in the human brain. This...
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Su(Hw) interacts with Combgap to establish long-range chromatin contacts
BackgroundInsulator-binding proteins (IBPs) play a critical role in genome architecture by forming and maintaining contact domains. While the...
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Chromatin profiling and state predictions reveal insights into epigenetic regulation during early porcine development
BackgroundGiven their physiological similarities to humans, pigs are increasingly used as model organisms in human-oriented biomedical studies....
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Roles of post-translational modifications of UHRF1 in cancer
UHRF1 as a member of RING-finger type E3 ubiquitin ligases family, is an epigenetic regulator with five structural domains. It has been involved in...
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Prenatal nicotine exposure leads to epigenetic alterations in peripheral nervous system signaling genes in the testis of the rat
BackgroundPrenatal nicotine exposure (PNE) has been documented to cause numerous deleterious effects on fetal development. However, the epigenetic...
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The probability of chromatin to be at the nuclear lamina has no systematic effect on its transcription level in fruit flies
BackgroundMultiple studies have demonstrated a negative correlation between gene expression and positioning of genes at the nuclear envelope (NE)...
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Histone proteoform analysis reveals epigenetic changes in adult mouse brown adipose tissue in response to cold stress
BackgroundRegulation of the thermogenic response by brown adipose tissue (BAT) is an important component of energy homeostasis with implications for...
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Reinforcement of repressive marks in the chicken primordial germ cell epigenetic signature: divergence from basal state resetting in mammals
BackgroundIn mammals, primordial germ cells (PGCs), the embryonic precursors of the germline, arise from embryonic or extra-embryonic cells upon...
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Analysis of long-range chromatin contacts, compartments and loo** between mouse embryonic stem cells, lens epithelium and lens fibers
BackgroundNuclear organization of interphase chromosomes involves individual chromosome territories, “open” and “closed” chromatin compartments,...
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The N-terminal dimerization domains of human and Drosophila CTCF have similar functionality
BackgroundCTCF is highly likely to be the ancestor of proteins that contain large clusters of C2H2 zinc finger domains, and its conservation is...
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Transcriptionally active chromatin loops contain both ‘active’ and ‘inactive’ histone modifications that exhibit exclusivity at the level of nucleosome clusters
Chromatin state is thought to impart regulatory function to the underlying DNA sequence. This can be established through histone modifications and...
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Incorporation of the histone variant H2A.Z counteracts gene silencing mediated by H3K27 trimethylation in Fusarium fujikuroi
BackgroundFusarium fujikuroi is a pathogen of rice causing diverse disease symptoms such as ‘ bakanae ’ or stunting, most likely due to the production...
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TP63–TRIM29 axis regulates enhancer methylation and chromosomal instability in prostate cancer
BackgroundProstate adenocarcinoma (PRAD) is the second leading cause of cancer-related deaths in men. High variability in DNA methylation and a high...
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Awareness, experiences, and opinions by owners, breeders, show judges, and veterinarians on canine Brachycephalic Obstructive Airway Syndrome (BOAS)
BackgroundExaggerated brachycephalic features have been highlighted over the last decade by their profound effect on the health and welfare of the...
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Intrafamily heterooligomerization as an emerging mechanism of methyltransferase regulation
Protein and nucleic acid methylation are important biochemical modifications. In addition to their well-established roles in gene regulation, they...
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Research progress of SWI/SNF complex in breast cancer
In the past decade, numerous epigenetic mechanisms have been discovered to be associated with cancer. The mammalian SWI/SNF complex is an...
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A low-input high resolution sequential chromatin immunoprecipitation method captures genome-wide dynamics of bivalent chromatin
BackgroundBivalent chromatin is an exemplar of epigenetic plasticity. This co-occurrence of active-associated H3K4me3 and inactive-associated...
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Demography, common disorders and mortality of Shih Tzu dogs under primary veterinary care in the UK
BackgroundShih Tzus are a popular dog breed in the UK although there is relatively little reported information on their health. This study aimed to...
