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Anti-Carbamylated Protein Antibodies in ACPA-Negative and ACPA-Positive Patients with Rheumatoid Arthritis
AbstractThe objective of this study was to assess the level of antibodies to carbamylated proteins and analyze the clinical and immunological...
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Clinical Features of ACPA-Negative and ACPA-Positive Variants of Rheumatoid Arthritis
AbstractThe aim of the study was to investigate the features of the clinical picture of the disease in patients with ACPA–negative and ACPA-positive...
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Proinflammatory Activation of Monocytes in Patients with Immunoinflammatory Rheumatic Diseases
AbstractThe pathogenesis of immunoinflammatory rheumatic diseases (IRDs) is based on chronic inflammation, one of the key mechanisms of which may be...
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The Prevalence and Factors Associated with Coronary Heart Disease in Patients with Gout
AbstractGout is associated with increased risk of cardiovascular disease (CVD) morbidity and mortality. Therefore, an association between coronary...
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Induction of the PERK-eIF2α-ATF4 Pathway in M1 Macrophages under Endoplasmic Reticulum Stress
AbstractTranslation inhibition can activate two cell death pathways. The first pathway is activated by translational aberrations, the second by...
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Fine map** of interspecific secondary CSSL populations revealed key regulators for grain weight at qTGW3.1 locus from Oryza nivara
Grain weight (GW) is the most important stable trait that directly contributes to crop yield in case of cereals. A total of 105 backcross...
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The Effect of Oxidative Stress and Antioxidants Treatment on Gestational Diabetes Mellitus Outcome: A Sco** Review
Diagnosing a pregnant woman’s glucose intolerance is referred to as gestational diabetes mellitus (GDM). Diabetes has been linked to enhanced...
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Basic Fibroblast Growth Factor Accumulation in Culture Medium Masks the Direct Antitumor Effect of Anti-VEGF Agent Bevacizumab
AbstractThe direct antitumor effect of bevacizumab (BEV) has long been debated. Evidence of the direct antitumor activities of drugs are mainly...
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Biophysical characterization of the phase separation of TDP-43 devoid of the C-terminal domain
BackgroundFrontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-TDP), amyotrophic lateral sclerosis (ALS) and limbic-predominant...
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Clinical Manifestations and Prognosis of Giant Cell Arteritis: A Retrospective Cohort Study
AbstractThe aim of the study was to evaluate the clinical manifestations and survival of patients with giant cell arteritis (GCA).
Materials and...
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The 3,3'-dimethoxy-4,4'-dihydroxy-stilbene Triazole (STT) Inhibits Liver Cancer Cell Growth by Targeting Akt/mTOR Pathway
AbstractThe present study was aimed to investigate the proliferation inhibitory ability of 3,3'-dimethoxy-4,4'-dihydroxy-stilbene triazole (STT) on...
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Homeotic DUX4 Genes Shape Dynamic Inter-Chromosomal Contacts with Nucleoli in Human Cells
AbstractNucleoli form interchromosomal contacts with genes controlling differentiation and carcinogenesis. DUX4 genes specify transcription factor...
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Blockade of PD-1 and TIM-3 Ameliorates CD8+ T Cell Exhaustion in a Mouse Model of Chronic Myeloid Leukemia
The immune system plays a pivotal role in controlling chronic myeloid leukemia (CML). CD8 + T cell exhaustion results in reduced effectiveness of T...
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Extrachromosomal circular DNA promotes prostate cancer progression through the FAM84B/CDKN1B/MYC/WWP1 axis
BackgroundExtrachromosomal circular DNA (eccDNA), a kind of circular DNA that originates from chromosomes, carries complete gene information,...
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Airways Relaxant and Antiasthmatic Activity of Aconitum heterophyllum Wall ex Royle. Roots: A Mechanistic Insight
Aconitum heterophyllum Wall ex Royle. (Ranunculaceae) is a traditional medicinal herb that has shown extensive pharmacological potential to treat...
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Navigating the complexity of p53-DNA binding: implications for cancer therapy
AbstractThe tumor suppressor protein p53, a transcription factor playing a key role in cancer prevention, interacts with DNA as its primary means of...
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“Effect of Sunset Yellow on Testis: Molecular Evaluation, and Protective Role of Coenzyme Q10 in Male Sprague-Dawley Rats”
In recent years, Sunset Yellow (SY) has been widely used as a food additive, sparking debates about its potential toxicity. This research aims to...
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Neuroprotective Effects of Dehydroepiandrosterone and Hericium erinaceus in Scopolamine-induced Alzheimer’s Diseases-like Symptoms in Male Rats
BackgroundThe neuroprotective effects of Dehydroepiandrosterone (DHEA) and Hericium erinaceus (H . erinaceus ) mushroom extract against...
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The Impact of the VEGF/VEGFR2/PI3K/AKT Signaling Axis on the Proliferation and Migration Abilities of Human Dental Pulp Stem Cells
The potential therapeutic benefits of human dental pulp stem cells (HDPSCs) in dental regenerative medicine have been demonstrated. However, little...
