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Rational construction of a high-quality and high-efficiency biosynthetic system and fermentation optimization for A82846B based on combinatorial strategies in Amycolatopsis orientalis
BackgroundOritavancin is a new generation of semi-synthetic glycopeptide antibiotics against Gram-positive bacteria, which served as the first and...
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Increased stable integration efficiency in CHO cells through enhanced nuclear localization of Bxb1 serine integrase
BackgroundMammalian display is an appealing technology for therapeutic antibody development. Despite the advantages of mammalian display, such as...
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Engineering strategies for enhanced 1′, 4′-trans-ABA diol production by Botrytis cinerea
BackgroundCurrently, industrial fermentation of Botrytis cinerea is a significant source of abscisic acid (ABA). The crucial role of ABA in plants...
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Chemical fingerprint analysis of fermented Morinda citrifolia L. (Noni) juice by UHPLC Q-TOF/MS combined with chemometric analysis
Morinda citrifolia L. (Noni) has been widely used in traditional medicine in tropical zones and has become increasingly popular globally owing to its...
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‘Small volume—big problem’: culturing Yarrowia lipolytica in high-throughput micro-formats
With the current progress in the ‘design’ and ‘build’ stages of the ‘design-build-test-learn’ cycle, many synthetic biology projects become...
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A comprehensive database of human and livestock fecal microbiome for community-wide microbial source tracking: a case study in South Korea
Fecal waste from livestock farms contains numerous pathogens, and improperly managed waste may flow into water bodies, causing water-borne diseases....
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Screening of Candida spp. in wastewater in Brazil during COVID-19 pandemic: workflow for monitoring fungal pathogens
Fungal diseases are often linked to poverty, which is associated with poor hygiene and sanitation conditions that have been severely worsened by the...
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Metabolic engineering of Saccharomyces cerevisiae for chelerythrine biosynthesis
BackgroundChelerythrine is an important alkaloid used in agriculture and medicine. However, its structural complexity and low abundance in nature...
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Biochar supplementation altered the expression of antioxidant proteins in rice leaf chloroplasts under high-temperature stress
In order to identify the key antioxidant defense systems used to cope with high-temperature stress in rice leaf chloroplasts following biochar...
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Metabolomic screening of anti-inflammatory compounds in Acanthopanax sessiliflorus fruit (Ogaza) extract
This study investigated the anti-inflammatory compounds in Ogaza, Acanthopanax sessiliflorus fruit, and their extracts using metabolomic screening....
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Efficient production of guanosine in Escherichia coli by combinatorial metabolic engineering
BackgroundGuanosine is a purine nucleoside that is widely used as a raw material for food additives and pharmaceutical products. Microbial...
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Transgenic Arabidopsis thaliana plants expressing bacterial γ-hexachlorocyclohexane dehydrochlorinase LinA
Backgroundγ-Hexachlorocyclohexane (γ-HCH), an organochlorine insecticide of anthropogenic origin, is a persistent organic pollutant (POP) that causes...
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Cytokinetic engineering enhances the secretory production of recombinant human lysozyme in Komagataella phaffii
BackgroundHuman lysozyme (hLYZ) is a natural antibacterial protein with broad applications in food and pharmaceutical industries. Recombinant...
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Volatile communication in Actinobacteria: a language for secondary metabolism regulation
BackgroundVolatile compounds are key elements in the interaction and communication between organisms at both interspecific and intraspecific levels....
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Novel fabrication of macromolecular multi-functional hydrogel encapsulated with HUCB-derived mesenchymal stem cells to effective regeneration of cardiac repair after acute myocardial infarction
Acute myocardial infarction (AMI) has been treated via injectable hydrogels and biomaterial patches invented using tissue engineering advancements...
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Comprehensive network of stress-induced responses in Zymomonas mobilis during bioethanol production: from physiological and molecular responses to the effects of system metabolic engineering
Nowadays, biofuels, especially bioethanol, are becoming increasingly popular as an alternative to fossil fuels. Zymomonas mobilis is a desirable...
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Ultrasound-assisted transesterification of waste cooking oil to biodiesel utilizing banana peel derived heterogeneous catalyst
Scientists are considering substitute energies as a consequence of the increasing global demand for energy. An eco-friendly and high flash point...
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Upcycling of tetra pack waste cellulose into reducing sugars for bioethanol production using Saccharomyces cerevisiae
Bioethanol production from waste materials offers a promising avenue for sustainable energy and waste management. In this study, fermentable sugars...
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Bi-directionalized promoter systems allow methanol-free production of hard-to-express peroxygenases with Komagataella Phaffii
BackgroundHeme-incorporating peroxygenases are responsible for electron transport in a multitude of organisms. Yet their application in biocatalysis...
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Integrated pathway mining and selection of an artificial CYP79-mediated bypass to improve benzylisoquinoline alkaloid biosynthesis
BackgroundComputational mining of useful enzymes and biosynthesis pathways is a powerful strategy for metabolic engineering. Through systematic...
