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Rescue of nucleus pulposus cells from an oxidative stress microenvironment via glutathione-derived carbon dots to alleviate intervertebral disc degeneration
The senescence of nucleus pulposus (NP) cells (NPCs), which is induced by the anomalous accumulation of reactive oxygen species (ROS), is a major...
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Macrophage membrane-reversibly camouflaged nanotherapeutics accelerate fracture healing by fostering MSCs recruitment and osteogenic differentiation
The fracture healing outcome is largely dependent on the quantities as well as osteogenic differentiation capacities of mesenchymal stem cells (MSCs)...
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Prediction method of pharmacokinetic parameters of small molecule drugs based on GCN network model
ContextAccurately predicting plasma protein binding rate (PPBR) and oral bioavailability (OBA) helps to better reveal the absorption and distribution...
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Ultrasound-responsive Bi2MoO6-MXene heterojunction as ferroptosis inducers for stimulating immunogenic cell death against ovarian cancer
BackgroundOvarian cancer (OC) has the highest fatality rate among all gynecological malignancies, necessitating the exploration of novel, efficient,...
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Potential of V-Si72, V-C72, and V-Al36N36 as catalysts for oxygen reduction reaction
ContextThe capacities of V-Si 72 , V-C 72 , and V-Al 36 N 36 nanocages to catalyze the ORR processes have been investigated. The acceptable pathways of ORR...
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Remote coupling of electrical and mechanical cues by diurnal photothermal irradiation synergistically promotes bone regeneration
Recapitulating the natural extracellular physical microenvironment has emerged as a promising method for tissue regeneration, as multiple physical...
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Targeting CSF1R in myeloid-derived suppressor cells: insights into its immunomodulatory functions in colorectal cancer and therapeutic implications
ObjectiveThis study aimed to investigate the critical role of MDSCs in CRC immune suppression, focusing on the CSF1R and JAK/STAT3 signaling axis....
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Insights into the variations of kinetic and potential energies in a multi-bond reaction: the reaction electronic flux perspective
ContextThe debate over whether kinetic energy (KE) or potential energy (PE) are the fundamental energy components that contribute to forming covalent...
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In silico-guided discovery and in vitro validation of novel sugar-tethered lysinated carbon nanotubes for targeted drug delivery of doxorubicin
ContextMultiwalled carbon nanotubes (MWCNTs) functionalized with lysine via 1,3-dipolar cycloaddition and conjugated to galactose or mannose are...
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Yoda1 pretreated BMSC derived exosomes accelerate osteogenesis by activating phospho-ErK signaling via Yoda1-mediated signal transmission
Segmental bone defects, arising from factors such as trauma, tumor resection, and congenital malformations, present significant clinical challenges...
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An end-to-end approach for single-cell infrared absorption spectroscopy of bacterial inclusion bodies: from AFM-IR measurement to data interpretation of large sample sets
BackgroundInclusion bodies (IBs) are well-known subcellular structures in bacteria where protein aggregates are collected. Various methods have...
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Study of the antidiabetic mechanism of berberine compound on FOXO1 transcription factor through molecular docking and molecular dynamics simulations
ContextDiabetes mellitus (DM) is a metabolic disorder disease that causes hyperglycemia conditions and associated with various chronic complications...
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IPSC-NSCs-derived exosomal let-7b-5p improves motor function after spinal cord Injury by modulating microglial/macrophage pyroptosis
BackgroundFollowing spinal cord injury (SCI), the inflammatory storm initiated by microglia/macrophages poses a significant impediment to the...
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Endothelial cells-derived exosomes-based hydrogel improved tendinous repair via anti-inflammatory and tissue regeneration-promoting properties
Tendon injuries are common orthopedic ailments with a challenging healing trajectory, especially in cases like the Achilles tendon afflictions. The...
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Molecular self-assembled helix peptide nanotubes based on some amino acid molecules and their dipeptides: molecular modeling studies
ContextThe paper considers the features of the structure and dipole moments of several amino acids and their dipeptides which play an important role...
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Bionanosensor utilizing single-layer graphene for the detection of iridovirus
ContextIridoviruses, a group of double-stranded DNA viruses, pose a significant threat to various aquatic animals, causing substantial economic...
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Ab initio investigation of the geometrical behavior in solution and electronic structure of the anion complexes [bis(1,3-dithiole-2-thione-4,5-dithiolate)M], for M = Bi(III), Sb(III), and Zn(II)
Context1,3-Dithiole-2-thione-4,5-dithiolate (dmit) ligands are known for their conductive and optical properties. Dmit compounds have been assessed...
