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Establishment of a multi-line immunochromatography based on magnetic nanoparticles for simultaneous screening of multiple biomarkers
Biomarkers screening is a benefit approach for early diagnosis of major diseases. In this study, magnetic nanoparticles (MNPs) have been utilized as...
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Rapid analysis of untreated food samples by gel loading tip spray ionization mass spectrometry
Rapid, efficient, versatile, easy-to-use, and non-expensive analytical approaches are globally demanded for food analysis. Many ambient ionization...
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Combination of real-time and hyphenated mass spectrometry for improved characterisation of exhaled breath biomarkers in clinical research
Exhaled breath volatilomics is a powerful non-invasive tool for biomarker discovery in medical applications, but compound annotation is essential for...
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Rapid immunochemical methods for the analysis of proquinazid in strawberry QuEChERS extracts
Proquinazid is a new-generation fungicide authorized in the EU for combating powdery mildew infections in high-value crops. Due to the perishable...
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Enantiomeric resolution of three profen drugs using direct thin-layer chromatographic method
This study presents the enantiomeric resolution of three profen drugs, viz ., flurbiprofen (FLB), fenoprofen, and zaltoprofen by employing...
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SERS and electrochemical dual-mode detection of miRNA-141 by using single Au@Ag nanowire as a new platform
As biomarkers of cancer, the accurate and sensitive detection of microRNAs is of great significance. Therefore, we proposed a surface-enhanced Raman...
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Binding studies of promethazine and its metabolites with human serum albumin by high-performance affinity chromatography and molecular docking in the presence of codeine
“Purple Drank”, a soft drink containing promethazine (PMZ) and codeine (COD), has gained global popularity for its hallucinogenic effects. Consuming...
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Identification and Semi-quantification of 36 Compounds from Violae herba (Zihuadiding) via UHPLC-Q-Orbitrap-MS/MS as Well as Proposal of Anti-counterfeiting Quality-Marker for Pharmacopeia
Violae herba (Zihuadiding) is a common Chinese herbal medicine. The current Chinese Pharmacopeia (ChP) defines Viola yedoensis Makino as the sole...
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Subzero project: comparing trace element profiles of enriched mitochondria fractions from frozen and fresh liver tissue
From organs to subcellular organelles, trace element (TE) homeostasis is fundamental for many physiological processes. While often overlooked in...
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Colorimetric enzymatic rapid test for the determination of atropine in baby food using a smartphone
A method for the enzymatic determination of atropine has been developed, which is based on a sequence of reactions involving (1) the hydrolysis of...
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Soft ionization mechanisms in flexible µ-tube plasma—from FµTP to closed µ-tube plasma
In order to find an explanation for the mechanism in a plasma operated with an alternating voltage, or rather a square wave voltage, such a plasma...
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15N metabolic labeling-TMT multiplexing approach to facilitate the quantitation of glycopeptides derived from cell lines
The study of glycoproteomics presents a set of unique challenges, primarily due to the low abundance of glycopeptides and their intricate...
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Experimental design optimisation and validation by accuracy profile of a novel method for Hg speciation analysis by HPLC-ICP-MS and application to Total Diet Studies
This study addresses the development and validation of an analytical method for speciation analysis of mercury (inorganic/Hg 2+ and methylmercury/CH 3 Hg
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Evaluation and clinical application of a bracketing calibration-based isotope dilution liquid chromatography-tandem mass spectrometry candidate reference measurement procedure for serum theophylline
A candidate reference measurement procedure (RMP) for serum theophylline via isotope dilution liquid chromatography-tandem mass spectrometry...
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DoE-Aided Optimization of RP-HPLC Method for Simultaneous Estimation of Amoxicillin and Tinidazole Loaded Mucoadhesive GRDDS Formulation for the Treatment of H. pylori
Helicobacter pylori (H. pylori) infection is one of the primary risk factors of peptic ulcer disease worldwide. Treatment of H. pylori with the...
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Sensitive detection of uric acid based on low-triggering-potential cathodic luminol electrochemiluminescence achieved by ReS2 nanosheets
The majority of previously reported cathodic electrochemiluminescence (ECL) systems often required very negative potential to be carried out, which...
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A novel AIE-based mitochondria-targeting fluorescent probe for monitoring of the fluctuation of endogenous hypochlorous acid in ferroptosis models
Ferroptosis is a way of cell death mainly due to the imbalance between the production and degradation of lipid reactive oxygen species, which is...
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Development and evaluation of a candidate reference measurement procedure for detecting 17α-hydroxyprogesterone in dried blood spots using isotope dilution liquid chromatography tandem mass spectrometry
17α-Hydroxyprogesterone (17α-OHP) quantification in dried blood spots (DBS) is essential for newborn screening for congenital adrenal hyperplasia...
