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Research Progress of ARTP Mutagenesis Technology Based on Citespace Visualization Analysis
Atmospheric and room temperature plasma (ARTP) mutagenesis technology has been developed rapidly in recent years because of its simple operation,...
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Oncogenic Gene CNOT7 Promotes Progression and Induces Poor Prognosis of Glioma
Glioma is the most common malignant brain tumor in the central nervous system with the poor prognosis of patients. The CNOT7 (CCR4-NOT Transcription...
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Intratumoral Delivery of Genetically Engineered Anti-IL-6 Trans-signaling Therapeutics
Interleukin-6 (IL-6) is a highly pro-inflammatory cytokine involved in the etiopathology of several inflammatory diseases and cancer. As so, the...
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Simultaneous multi-site editing of individual genomes using retron arrays
During recent years, the use of libraries-scale genomic manipulations scaffolded on CRISPR guide RNAs have been transformative. However, these...
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Engineering miniature IscB nickase for robust base editing with broad targeting range
IscB has a similar domain organization to Cas9, but the small size of IscB is better suited for delivery by adeno-associated virus. To improve the...
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Cas1 mediates the interference stage in a phage-encoded CRISPR–Cas system
Clustered regularly interspaced short palindromic repeats (CRISPR)–Cas systems are prokaryotic adaptive immune systems against invading phages and...
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Distinct phases of cellular signaling revealed by time-resolved protein synthesis
The post-translational regulation of protein function is involved in most cellular processes. As such, synthetic biology tools that operate at this...
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Assessing and engineering the IscB–ωRNA system for programmed genome editing
OMEGA RNA (ωRNA)-guided endonuclease IscB, the evolutionary ancestor of Cas9, is an attractive system for in vivo genome editing because of its...
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Programmed RNA editing with an evolved bacterial adenosine deaminase
Programmed RNA editing presents an attractive therapeutic strategy for genetic disease. In this study, we developed bacterial deaminase-enabled...
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Genetically programmed synthetic cells for thermo-responsive protein synthesis and cargo release
Synthetic cells containing genetic programs and protein expression machinery are increasingly recognized as powerful counterparts to engineered...
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Research Hotspots and Development Trends on Apolipoprotein B in the Field of Atherosclerosis: A Bibliometric Analysis
BackgroundCardiovascular diseases caused by atherosclerosis (AS) are the leading causes of disability and death worldwide. Apolipoprotein B (ApoB),...
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Recruitment of FBXO22 for targeted degradation of NSD2
Targeted protein degradation (TPD) is an emerging therapeutic strategy that would benefit from new chemical entities with which to recruit a wider...
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A CRISPR activation screen identifies FBXO22 supporting targeted protein degradation
Targeted protein degradation (TPD) represents a potent chemical biology paradigm that leverages the cellular degradation machinery to...
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Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1
Biochemical crosstalk between two or more histone modifications is often observed in epigenetic enzyme regulation, but its functional significance in...
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In Silico Drug Repurposing Against PSMB8 as a Potential Target for Acute Myeloid Leukemia Treatment
PSMB8 emerges as a prominent gene associated with cancer survival, yet its potential therapeutic role in acute myeloid leukemia (AML) remains...
