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Functional and clinical roles of stromal PDGF receptors in tumor biology
PDGF receptors play pivotal roles in both developmental and physiological processes through the regulation of mesenchymal cells involved in paracrine...
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Dual targeting non-overlap** epitopes in HER2 domain IV substantially enhanced HER2/HER2 homodimers and HER2/EGFR heterodimers internalization leading to potent antitumor activity in HER2-positive human gastric cancer
BackgroundTrastuzumab and pertuzumab combination has been approved for the treatment of patients with HER2-positive metastatic breast cancer....
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ErbB4 deficiency exacerbates olfactory dysfunction in an early-stage Alzheimer’s disease mouse model
Olfactory dysfunction is increasingly recognized as an early indicator of Alzheimer’s disease (AD). Aberrations in GABAergic function and the...
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Neural substrates for regulating self-grooming behavior in rodents
Grooming, as an evolutionarily conserved repetitive behavior, is common in various animals, including humans, and serves essential functions...
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Validating genetic variants in innate immunity linked to infectious events in acute myeloid leukemia post-induction chemotherapy
Infectious events, such as sepsis and invasive fungal disease (IFD), pose significant risks in patients with acute myeloid leukemia (AML). Previous...
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Ethnic-specific genetic susceptibility loci for endometriosis in Taiwanese-Han population: a genome-wide association study
Endometriosis is a common gynecological disorder affecting around 10% of reproductive-age women. Although many hypotheses were proposed, genetic...
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Metabolic profiling reveals circulating biomarkers associated with incident and prevalent Parkinson’s disease
The metabolic profile predating the onset of Parkinson’s disease (PD) remains unclear. We aim to investigate the metabolites associated with incident...
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Immune-checkpoint inhibitor-mediated myocarditis: CTLA4, PD1 and LAG3 in the heart
Immune-checkpoint inhibitors (ICIs) have revolutionized oncology, with nearly 50% of all patients with cancer eligible for treatment with ICIs....
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Sensing and guiding cell-state transitions by using genetically encoded endoribonuclease-mediated microRNA sensors
Precisely sensing and guiding cell-state transitions via the conditional genetic activation of appropriate differentiation factors is challenging....
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Mechanical deformation and death of circulating tumor cells in the bloodstream
The circulation of tumor cells through the bloodstream is a significant step in tumor metastasis. To better understand the metastatic process,...
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Analysis of the immune-inflammatory indices for patients with metastatic hormone-sensitive and castration-resistant prostate cancer
BackgroundInflammation plays a pivotal role in the progression of prostate cancer (PCa). Several immune-inflammatory indices, including neutrophil to...
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Recursive partitioning analysis for survival stratification and early imaging prediction of molecular biomarker in glioma patients
BackgroundGlioma is the most common primary brain tumor with high mortality and disability rates. Recent studies have highlighted the significant...
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Prospective modeling and estimating the epidemiologically informative match rate within large foodborne pathogen genomic databases
ObjectivesMuch has been written about the utility of genomic databases to public health. Within food safety these databases contain data from two...
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IκBα kinase inhibitor BAY 11-7082 promotes anti-tumor effect in RAS-driven cancers
BackgroundOncogenic mutations in the RAS gene are associated with uncontrolled cell growth, a hallmark feature contributing to tumorigenesis. While...
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Flexible multitask computation in recurrent networks utilizes shared dynamical motifs
Flexible computation is a hallmark of intelligent behavior. However, little is known about how neural networks contextually reconfigure for different...
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Quinoa and its Co-Products as Ingredients for the Development of Dairy Analogs and Hybrid Dairy Products
Purpose of ReviewThis review intends to explore the potential of quinoa and its co-products as ingredients to alternative dairy foods (plant-based...
