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GIS-based spatiotemporal map** of malaria prevalence and exploration of environmental inequalities
Malaria poses a significant threat to global health, with particular severity in Nigeria. Understanding key factors influencing health outcomes is...
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Association of HLA-G 3′UTR polymorphisms with hepatitis B virus infection in Tunisian population
Hepatitis B virus (HBV) infection is a major public health burden. The mechanisms of immune evasion during chronic HBV (CHB) infection are poorly...
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Yixin-Fumai granules modulate autophagy through the PI3K/AKT/FOXO pathway and lead to amelioration of aging mice with sick sinus syndrome
ObjectiveBy employing network pharmacology alongside molecular docking techniques, we can delve into the intricate workings of Yixin-Fumai granules...
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Alteration of β-glucan in the emerging fungal pathogen Candida auris leads to immune evasion and increased virulence
Candida auris is an emerging pathogenic yeast that has been categorized as a global public health threat and a critical priority among fungal...
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Island hitchhikers: pathogen agents of Madeira and Azores ticks
Ticks are blood-sucking arthropods that can transmit pathogens to their host. As insular ecosystems can enhance tick-host interactions, this study...
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lncRNA FGD5-AS1 is required for gastric cancer proliferation by inhibiting cell senescence and ROS production via stabilizing YBX1
BackgroundThe vast majority of lncRNAs have low expression abundance, which greatly limits their functional range and impact. As a high expression...
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Positive feedback loop of c-myc/XTP6/NDH2/NF-κB to promote malignant progression in glioblastoma
BackgroundRecent studies have highlighted the significant role of the NF-κB signaling pathway in the initiation and progression of cancer....
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Elastin-derived peptides (EDPs) as a potential pro-malignancy factor in human leukemia cell lines
AbstractThe extracellular matrix (ECM) is currently considered to be an important factor influencing the migration and progression of cancer cells....
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Epigenetic recording of stimulation history reveals BLIMP1–BACH2 balance in determining memory B cell fate upon recall challenge
Memory B cells (MBCs) differentiate into plasma cells (PCs) or germinal centers (GCs) upon antigen recall. How this decision is programmed is not...
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Sodium Houttuyfonate Ameliorates DSS-induced Colitis Aggravated by Candida albicans through Dectin-1/NF-κB/miR-32-5p/NFKBIZ Axis Based on Intestinal microRNA Profiling
Our previous research indicated that Sodium houttuyfonate (SH) can effectively ameliorate dextran sulfate sodium (DSS)-induced colitis exacerbated by C...
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Kinin B1 receptor and TLR4 interaction in inflammatory response
ObjectiveWe aimed to broaden our understanding of a potential interaction between B1R and TLR4, considering earlier studies suggesting that...
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Chemical composition and studying the possible neuroprotective effect of iridoids-rich fraction from Pentas lanceolata leaves using rotenone model of Parkinson’s disease in mice
Parkinsonism is an age-related neurodegenerative illness that affects motor coordination leading to loss of dopaminergic neurons. Many medications...
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NLRP3 (rs10754558) gene polymorphism and tumor necrosis factor alpha as predictors for disease activity and response to methotrexate and adalimumab in psoriasis
BackgroundPsoriasis has a global prevalence of 1–3%, with variations observed across different ethnic groups and geographical areas. Disease...
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A novel lncRNA LOC101928222 promotes colorectal cancer angiogenesis by stabilizing HMGCS2 mRNA and increasing cholesterol synthesis
BackgroundMetastasis is the leading cause of mortality in patients with colorectal cancer (CRC) and angiogenesis is a crucial factor in tumor...
