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Article
Patterns and conformations of commonly occurring supersecondary structures (basic motifs) in protein data bank
Short peptides connectingα-helices andβ-strands have been analyzed in 240 proteins refined at resolutions of 0.25 nm or better. Connecting peptides of lengths between one and five residues have been classified as...
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Article
The evolution simulation of zinc finger domain sequence
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Applying genetic algorithms to the study of protein mutation theory
Genetic algorithms were applied to the study of simulation of protein mutation carried out on two-dimensional lattice model; to the study of effects of single mutation and double mutation on protein folding an...
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Article
Protein Structure Prediction in a 210-Type Lattice Model: Parameter Optimization in the Genetic Algorithm Using Orthogonal Array
We have applied the orthogonal array method to optimize the parameters in the genetic algorithm of the protein folding problem. Our study employed a 210-type lattice model to describe proteins, where the orientat...
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Article
A new method of research on molecular evolution of proteinase superfamily
The molecular evolutionary tree, also known as a phylogenetic tree, of the serine proteinase superfamily was constructed by means of structural alignment. Three-dimensional structures of proteins were aligned ...
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Article
Bioinformatical study on the proteomics and evolution of SARS-CoV
A novel coronavirus has been identified as the causative agent of the severe acute respiratory syndrome (SARS). For all the SARS-CoV associated proteins derivated from the SARS-CoV genome, the physiochemical p...
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Article
Structural and functional characterization of the human CCR5 receptor in complex with HIV gp120 envelope glycoprotein and CD4 receptor by molecular modeling studies
The entry of human immunodeficiency virus (HIV) into cells depends on a sequential interaction of the gp120 envelope glycoprotein with the cellular receptors CD4 and members of the chemokine receptor family. T...
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Article
Open AccessNBA-Palm: prediction of palmitoylation site implemented in Naïve Bayes algorithm
Protein palmitoylation, an essential and reversible post-translational modification (PTM), has been implicated in cellular dynamics and plasticity. Although numerous experimental studies have been performed to...
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Article
GO molecular function coding based protein subcellular localization prediction
Subcellular localization is an important feature of proteins which is closely correlated to their function. In this work, we tried to develop a new coding method of using those location predictive molecular fu...
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Article
Open AccessDBMLoc: a Database of proteins with multiple subcellular localizations
Subcellular localization information is one of the key features to protein function research. Locating to a specific subcellular compartment is essential for a protein to function efficiently. Proteins which h...
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Article
Open AccessMolecular evolution of Cide family proteins: Novel domain formation in early vertebrates and the subsequent divergence
Cide family proteins including Cidea, Cideb and Cidec/Fsp27, contain an N-terminal CIDE-N domain that shares sequence similarity to the N-terminal CAD domain (NCD) of DNA fragmentation factors Dffa/Dff45/ICAD ...
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Article
Open AccessInferring protein function by domain context similarities in protein-protein interaction networks
Genome sequencing projects generate massive amounts of sequence data but there are still many proteins whose functions remain unknown. The availability of large scale protein-protein interaction data sets make...
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Article
Witness the prosperity: 25 years of life science revival in Tsinghua University
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Identifying changed protein-protein interactions in biological processes by gene coexpression analysis
The interaction strength between 2 proteins is not constant but variable under different conditions. For a given biological process, identification of protein-protein interactions (PPIs) undergoing dynamic cha...
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Article
Preparation and characterization of Pd/PPy-SDS/foam-Ni and Pd/PPy-CTAB/foam-Ni electrodes with high electroactive surface area
Surfactant-doped electrodes, palladium/polymeric pyrrole-sodium dodecyl sulfate/foam-nickel (Pd/PPy-SDS/foam-Ni) electrode and palladium/polymeric pyrrole-cetyl trimethyl ammonium bromide/foam-nickel (Pd/PPy-C...
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Article
Open AccessCancer core modules identification through genomic and transcriptomic changes correlation detection at network level
Identification of driver mutations among numerous genomic alternations remains a critical challenge to the elucidation of the underlying mechanisms of cancer. Because driver mutations by definition are associa...
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Article
Propofol Protects Against Angiotensin II-Induced Mouse Hippocampal HT22 Cells Apoptosis Via Inhibition of p66Shc Mitochondrial Translocation
Hippocampal neuronal oxidative stress and apoptosis have been reported to be involved in cognitive impairment, and angiotensin II could induce hippocampal oxidative stress and apoptosis. Propofol is a widely ...
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Article
Dechlorination of pentachlorophenol (PCP) in aqueous solution on novel Pd-loaded electrode modified with PPy–SDBS composite film
Pentachlorophenol (PCP) is a persistent pollutant and a suspected human carcinogen. It can be found in the air, water, and soil and enters the environment through evaporation from treated wood surfaces, indust...
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Article
Preparation and electrochemical properties of SnO2-Sb-Ni-Ce oxide anode for phenol oxidation
A novel Ni-Ce co-doped SnO2-Sb anode with macroporous titanium sheet as substrate (mp-Ti/SnO2-Sb-Ni-Ce anode) was prepared by modified sol–gel method. The surface morphology, the crystal structure, and the valenc...
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Article
Surgical trauma induces postoperative T-cell dysfunction in lung cancer patients through the programmed death-1 pathway
The programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) pathway have been shown to be involved in tumor-induced and sepsis-induced immunosuppression. However, whether this pathway is involved in th...