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FXR activation remodels hepatic and intestinal transcriptional landscapes in metabolic dysfunction-associated steatohepatitis

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  1. Article

    Open Access

    Search for the \( {B}_s^0 \) → μ+μγ decay

    A search for the fully reconstructed B s 0 ...

    R. Aaij, A. S. W. Abdelmotteleb, C. Abellan Beteta in Journal of High Energy Physics (2024)

  2. Article

    Open Access

    Mining the interpretable prognostic features from pathological image of intrahepatic cholangiocarcinoma using multi-modal deep learning

    The advances in deep learning-based pathological image analysis have invoked tremendous insights into cancer prognostication. Still, lack of interpretability remains a significant barrier to clinical application.

    Guang-Yu Ding, Wei-Min Tan, You-Pei Lin, Yu Ling, Wen Huang, Shu Zhang in BMC Medicine (2024)

  3. Article

    Open Access

    Reformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation

    Fully targeted mRNA therapeutics necessitate simultaneous organ-specific accumulation and effective translation. Despite some progress, delivery systems are still unable to fully achieve this. Here, we reformu...

    Kexin Su, Lu Shi, Tao Sheng, **nxin Yan, Lixin Lin, Chaoyang Meng in Nature Communications (2024)

  4. Article

    Open Access

    R2-ISS staging combined with circulating plasma cells improves risk stratification for newly diagnosed multiple myeloma: a single-center real-world study

    We aimed to evaluate if circulating plasma cells (CPC) detected by flow cytometry could add prognostic value of R2-ISS staging. We collected the electronic medical records of 336 newly diagnosed MM patients (N...

    Bin Chu, Yu-tong Wang, Shan Gao, Lei Shi, Min-qiu Lu, Li-juan Fang in Annals of Hematology (2024)

  5. Article

    Open Access

    Association of elevated circulating monocyte-platelet aggregates with hypercoagulability in patients with nephrotic syndrome

    Hypercoagulability emerges as a central pathological feature and clinical complication in nephrotic syndrome. Increased platelet activation and aggregability are closely related to hypercoagulability in nephro...

    Shi-** Na, Mei-Liang Ning, Ji-Fang Ma, Shuang Liang, Yan-Li Wang in Thrombosis Journal (2024)

  6. Article

    Open Access

    Role of liver sinusoidal endothelial cell in metabolic dysfunction-associated fatty liver disease

    Liver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells that represent the interface between blood cells on one side and hepatocytes on the other side. LSECs not only form a barrier...

    Qiongyao He, Wu He, Hui Dong, Yu** Guo, Gang Yuan in Cell Communication and Signaling (2024)

  7. Article

    Open Access

    Search for central exclusive production of top quark pairs in proton-proton collisions at \( \sqrt{s} \) = 13 TeV with tagged protons

    A search for the central exclusive production of top quark-antiquark pairs ( t t ...

    A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer in Journal of High Energy Physics (2024)

  8. Article

    Open Access

    Measurements of electroweak W±Z boson pair production in association with two jets in pp collisions at \( \sqrt{s} \) = 13 TeV with the ATLAS detector

    Measurements of integrated and differential cross-sections for electroweak W±Z production in association with two jets (W±Zjj) in proton-proton collisions are presented. The data collected by the ATLAS detector a...

    G. Aad, E. Aakvaag, B. Abbott, S. Abdelhameed, K. Abeling in Journal of High Energy Physics (2024)

  9. Article

    Open Access

    Correction to: Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2V617F-induced myeloproliferative neoplasms

    Mengshi Hu, Tao Yang, Linyu Yang, Lu Niu, **bing Zhu, Ailin Zhao in Blood Cancer Journal (2024)

  10. Article

    Open Access

    LINC00525 enhances ZNF460-regulated CD24 expression through the sponge miR-125a-5p to promote malignant progression of breast cancer

    CD24 is a highly glycosylated glycosylphosphatidylinositol anchored membrane protein that plays an important role in tumor progression. The aim of this study was to investigate the effect of abnormal expressio...

    Jun Wang, Ji Shi, Yuan **ang, Zhi-Wen Wang in Journal of Cancer Research and Clinical On… (2024)

  11. Article

    Open Access

    Clinical efficacy and prognostic factors of CT-guided radioactive iodine-125 seed implantation for the treatment of superficial soft tissue metastasis: a 12-year retrospective analysis

    Superficial soft tissue metastasis (S-STM) of malignant tumors is uncommon and often brings great pain to patients. However, current treatment options are limited. The purpose of this study was to explore the ...

    Weiguang Qiang, Hongbing Shi, Bai Sun, Hao Wang, Chao Wang, Ye Yuan in Radiation Oncology (2024)

  12. Article

    Open Access

    Identification of lipid-modifying drug targets for autoimmune diseases: insights from drug target mendelian randomization

    A growing body of evidence has highlighted the interactions of lipids metabolism and immune regulation. Nevertheless, there is still a lack of evidence regarding the causality between lipids and autoimmune dis...

    **ao Hu, Peng Zhang, Yuan Gao, Wen-Wen Ding, Xue-Er Cheng in Lipids in Health and Disease (2024)

  13. Article

    Open Access

    Camrelizumab-based induction chemoimmunotherapy in locally advanced stage hypopharyngeal carcinoma: phase II clinical trial

    This phase II trial aimed to determine the efficacy and safety of induction chemoimmunotherapy of camrelizumab plus modified TPF in locally advanced hypopharyngeal squamous cell carcinoma (LA HSCC) (NCT0415669...

    Hongli Gong, Shu Tian, Hao Ding, Lei Tao, Li Wang, Jie Wang in Nature Communications (2024)

  14. Article

    Open Access

    WeChat assisted electronic symptom measurement for patients with adenomyosis

    Symptom assessment is central to appropriate adenomyosis management. Using a WeChat mini-program-based portal, we aimed to establish a valid symptom assessment scale of adenomyosis (AM-SAS) to precisely and ti...

    Wei Xu, **n Zhang, Fan Xu, Yuan Yuan in BMC Medical Informatics and Decision Making (2024)

  15. Article

    Open Access

    Pyrotinib and trastuzumab plus palbociclib and fulvestrant in HR+/HER2+ breast cancer patients with brain metastasis

    Human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC) patients are at a high risk of develo** metastases in the brain. However, research focusing on treatment strategies for hormonal r...

    Dongshao Chen, Fei Xu, Yongkui Lu, Wen **a, Caiwen Du, Dun **ong in npj Breast Cancer (2024)

  16. Article

    Open Access

    A Bibliometric Analysis of the Spatial Transcriptomics Literature from 2006 to 2023

    In recent years, spatial transcriptomics (ST) research has become a popular field of study and has shown great potential in medicine. However, there are few bibliometric analyses in this field. Thus, in this s...

    Shu-Han Zhao, **n-Yu Ji, Guo-Zhen Yuan, Tao Cheng in Cellular and Molecular Neurobiology (2024)

  17. Article

    Open Access

    Metabolism of alcohol ethoxylates (AEs) in rat, hamster, and human hepatocytes and liver S9: a pilot study for metabolic stability, metabolic pathway, and metabolites identification in vitro and in silico

    Alcohol ethoxylates (AEs) are a well-known class of non-ionic surfactants widely used by the personal care market. The aim of this study was to evaluate and characterize the in vitro metabolism of AEs and iden...

    Quan Shi, Stefan Moors, James Dawick, Lauren Kavanagh in Archives of Toxicology (2024)

  18. Article

    Open Access

    Association between a body shape index and prostate cancer: a cross-sectional study of NHANES 2001–2018

    Abdominal obesity, especially visceral fat, may have negative effects on the development and progression of prostate cancer (PCa). A body shape index (ABSI) can more accurately measure visceral fat accumulatio...

    **aowu Liu, Honglei Shi, Yunfeng Shi, Han** Wei in International Urology and Nephrology (2024)

  19. Article

    Open Access

    Search for a new resonance decaying into two spin-0 bosons in a final state with two photons and two bottom quarks in proton-proton collisions at \( \sqrt{s} \) = 13 TeV

    A search for a new boson X is presented using CERN LHC proton-proton collision data collected by the CMS experiment at ...

    A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer in Journal of High Energy Physics (2024)

  20. Article

    Open Access

    Two-dimensional materials for future information technology: status and prospects

    Over the past 70 years, the semiconductor industry has undergone transformative changes, largely driven by the miniaturization of devices and the integration of innovative structures and materials. Two-dimensi...

    Hao Qiu, Zhihao Yu, Tiange Zhao, Qi Zhang in Science China Information Sciences (2024)

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