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  1. Article

    Open Access

    Glucocorticoid receptor and Histone deacetylase 6 mediate the differential effect of dexamethasone during osteogenesis of mesenchymal stromal cells (MSCs)

    Lineage commitment and differentiation of mesenchymal stromal cells (MSCs) into osteoblasts in vitro is enhanced by a potent synthetic form of glucocorticoid (GC), dexamethasone (Dex). Paradoxically, when used ch...

    Marilyn G. Rimando, Hao-Hsiang Wu, Yu-An Liu, Chien-Wei Lee… in Scientific Reports (2016)

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  2. Article

    Open Access

    Bio- chemical and physical characterizations of mesenchymal stromal cells along the time course of directed differentiation

    Cellular biophysical properties are novel biomarkers of cell phenotypes which may reflect the status of differentiating stem cells. Accurate characterizations of cellular biophysical properties, in conjunction...

    Yin-Quan Chen, Yi-Shiuan Liu, Yu-An Liu, Yi-Chang Wu… in Scientific Reports (2016)

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  3. Article

    Open Access

    Mechanosensitive TRPM7 mediates shear stress and modulates osteogenic differentiation of mesenchymal stromal cells through Osterix pathway

    Microenvironments that modulate fate commitments of mesenchymal stromal cells (MSCs) are composed of chemical and physical cues, but the latter ones are much less investigated. Here we demonstrate that intermi...

    Yi-Shiuan Liu, Yu-An Liu, Chin-**g Huang, Meng-Hua Yen… in Scientific Reports (2015)

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