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  1. Article

    Open Access

    The neural and genetic underpinnings of different developmental trajectories of Attention-Deficit/Hyperactivity Symptoms in children and adolescents

    The trajectory of attention-deficit hyperactivity disorder (ADHD) symptoms in children and adolescents, encompassing descending, stable, and ascending patterns, delineates their ADHD status as remission, persi...

    Yanpei Wang, Leilei Ma, Jiali Wang, Yuyin Ding, Ningyu Liu, Weiwei Men in BMC Medicine (2024)

  2. Article

    Open Access

    Mid- and long-term risk of atrial fibrillation among breast cancer surgery survivors

    The risk of incident atrial fibrillation (AF) among breast cancer survivors, especially for younger women, and cancer treatment effects on the association remain unclear. This study aimed to investigate the ri...

    Yong-Moon Mark Park, Wonyoung Jung, Yohwan Yeo, Sang Hyun Park in BMC Medicine (2024)

  3. Article

    Open Access

    Comparison between the mesenteric fixation method (MEFIX) and conventional methods at preventing the occurrence of Petersen’s hernia: a study protocol for a multicenter randomized controlled trial

    Petersen’s hernia, which occurs after Billroth-II (B-II) or Roux-en-Y (REY) anastomosis, can be reduced by defect closure. This study aims to compare the incidence of bowel obstruction above Clavien–Dindo clas...

    Jae Kyun Park, Dae Hwan Kim, Tae-Yong Jeon, Sang-Ho Jeong, Tae Han Kim in Trials (2024)

  4. Article

    Open Access

    Effect of intubation in the lateral position under general anesthesia induction on the position of double-lumen tube placement in patients undergoing unilateral video-assisted thoracic surgery: study protocol for a prospective, single-center, parallel group, randomized, controlled trial

    The double-lumen tube (DLT) is an essential equipment for thoracic anesthesia and the precise position of DLT placement is particularly important for anesthesia and surgery. However, the incidence of DLT malpo...

    ** Zhang, Dong-Xu Wang, Qin Zhang, Qi-Bin Shen, Fei Tong, Yong-He Hu in Trials (2023)

  5. Article

    Open Access

    A multi-center, single-arm, phase II study of anlotinib plus paclitaxel and cisplatin as the first-line therapy of recurrent/advanced esophageal squamous cell carcinoma

    Anlotinib, a tyrosine kinase inhibitor, has shown encouraging anti-tumor activity in esophageal squamous cell carcinoma (ESCC). This study was designed to assess the efficacy and safety of anlotinib plus pacli...

    Ning Li, Tao Wu, Yong-Gui Hong, Yan-Zhen Guo, Yu-Feng Cheng, Yi-Jie Ma in BMC Medicine (2022)

  6. Article

    Open Access

    PRE-OPerative ECHOcardiograhy for prevention of cardiovascular events after non-cardiac surgery in intermediate- and high-risk patients: protocol for a low-interventional, mixed-cohort prospective study design (PREOP-ECHO)

    Cardiac evaluation using transthoracic echocardiography before noncardiac surgery is common in real-world practice. However, evidence supporting preoperative echocardiography is lacking. This study aims to eva...

    Eun Kyoung Kim, Hong-Mi Choi, Eui-Young Choi, Hye Sun Lee, Goeun Park in Trials (2022)

  7. Article

    Open Access

    Systemic immune inflammation index and system inflammation response index are potential biomarkers of atrial fibrillation among the patients presenting with ischemic stroke

    Chronic inflammatory disorders in atrial fibrillation (AF) contribute to the onset of ischemic stroke. Systemic immune inflammation index (SIII) and system inflammation response index (SIRI) are the two novel ...

    Kai-bin Lin, Feng-hua Fan, Ming-qi Cai, Yin Yu in European Journal of Medical Research (2022)

  8. Article

    Open Access

    Identification of ACOT13 and PTGER2 as novel candidate genes of autosomal dominant polycystic kidney disease through whole exome sequencing

    Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic kidney disorder. Half of the patients would slowly progress to end-stage renal disease. However, the potential target for ADPKD...

    Na Du, Dan Dong, Luyao Sun, Lihe Che, **aohua Li in European Journal of Medical Research (2021)

  9. Article

    Open Access

    Hydrocortisone to treat early bronchopulmonary dysplasia in very preterm infants: study protocol for a randomized controlled trial

    Bronchopulmonary dysplasia (BPD) is still a common complication in very premature infants. At present, there is no effective treatment for BPD. Glucocorticoids are drugs commonly used to prevent or treat BPD b...

    Yuan He, Yong Zhang, Shuqiang Gao, **aoling Wang, Na He, Deshuang Zhang in Trials (2020)

  10. Article

    Open Access

    Safety and efficacy of PG102P for the control of pruritus in patients undergoing hemodialysis (SNUG trial): study protocol for a randomized controlled trial

    Pruritus in patients undergoing hemodialysis is a highly prevalent complication that affects quality of life. Several medications are currently used for the treatment of uremic pruritus, but these are not sati...

    Yong Chul Kim, Jae Yoon Park, Sohee Oh, Jang-Hee Cho, Jae Hyun Chang in Trials (2019)

  11. Article

    Open Access

    Cervicogenic headache treated by acupuncture based on ** theory: study protocol for a randomized controlled trial

    Numerous randomized trials involving acupuncture treatment for cervicogenic headache (CEH) have been conducted in recent years, but the evidence for its effectiveness is not clear. Hence, we designed a randomi...

    Youkang Dong, Taipin Guo, Lei Xu, Chunlin Wang, Guanfen Wen, Zhiyong Zhao in Trials (2019)

  12. Article

    Open Access

    Comparison of effectiveness between warm acupuncture with local-distal points combination and local distribution points combination in breast cancer-related lymphedema patients: a study protocol for a multicenter, randomized, controlled clinical trial

    Lymphedema is the most common complication after breast cancer treatment, but management of lymphedema remains a clinical challenge. Several studies have reported the beneficial effect of acupuncture for treat...

    Chien-Hung Yeh, Tian Yi Zhao, Mei Dan Zhao, Yue Wu, Yong Ming Guo, Zhan Yu Pan in Trials (2019)

  13. Article

    Open Access

    Fimasartan versus perindopril with and without diuretics in the treatment of elderly patients with essential hypertension (Fimasartan in the Senior Subjects (FITNESS)): study protocol for a randomized controlled trial

    Hypertension is an important risk factor for cardiovascular disease, even in the elderly. Fimasartan is a new non-peptide angiotensin II receptor blocker with a selective type I receptor blocking effect. The o...

    Min-gu Kang, Kwang-il Kim, Sang Hyun Ihm, Moo-Yong Rhee, Il Suk Sohn in Trials (2019)

  14. Article

    Open Access

    The cerebral mechanism of acupuncture for treating knee osteoarthritis: study protocol for a randomized controlled trial

    Acupuncture is safe and effective for reducing the symptoms of knee osteoarthritis (KOA), but the underlying mechanisms of acupuncture for treating KOA are not fully understood.

    **g Guo, Yang Chen, Zhengjie Li, Shirui Cheng, Chenjian Tang, **aohui Dong in Trials (2019)

  15. Article

    Open Access

    Cerebral mechanism of celecoxib for treating knee pain: study protocol for a randomized controlled parallel trial

    Celecoxib is frequently prescribed to treat knee osteoarthritis (KOA), but how celecoxib influences the activity of the central nervous system to alleviate chronic pain remains unclear.

    Chenjian Tang, **aohui Dong, Wenhua He, Shirui Cheng, Yang Chen, Yong Huang in Trials (2019)

  16. Article

    Open Access

    Traditional Chinese medicine (TCM) collaborative care for patients with axial spondyloarthritis (AcuSpA): protocol for a pragmatic randomized controlled trial

    Axial spondyloarthritis (AxSpA) is a chronic disease which results in fatigue, pain, and reduced quality of life (QoL). Traditional Chinese medicine (TCM), especially acupuncture, has shown promise in managing...

    Yu Heng Kwan, Warren Fong, **ang Ling Ang, Chuen Seng Tan, Bee Choo Tai in Trials (2019)

  17. Article

    Open Access

    Effect of dual-acupoint and single-acupoint electric stimulation on postoperative outcomes in elderly patients subjected to gastrointestinal surgery: study protocol for a randomized controlled trial

    Transcutaneous electric acupoint stimulation (TEAS) has shown benefits when used peri-operatively. However, the role of numbers of areas with acupoint stimulation is still unclear. Therefore, we report the pro...

    Zhi-hong Lu, Hai-long Dong, Jia-wen Huang-fu, **ao-jian Fan, Wei-xian Zhao in Trials (2018)

  18. Article

    Open Access

    The efficacy and safety of herbal medicine BHH10 in postmenopausal women with osteoporosis: study protocol for a phase II, multicenter, randomized, double-blinded, placebo-controlled clinical trial

    Osteoporosis is becoming more prevalent in aging societies worldwide, and the economic burden attributable to osteoporotic fractures is substantial. The medications presently available to treat osteoporosis ha...

    Yeeun Cho, Seunghoon Lee, Jihye Kim, Jung Won Kang, Yong-Hyeon Baek in Trials (2018)

  19. Article

    Open Access

    Study design and rationale of the ‘Balloon-Expandable Cobalt Chromium SCUBA Stent versus Self-Expandable COMPLETE-SE Nitinol Stent for the Atherosclerotic ILIAC Arterial Disease (SENS-ILIAC Trial) Trial’: study protocol for a randomized controlled trial

    The self-expandable COMPLETE™ stent (Medtronic) has greater elasticity, allowing it to regain its shape after the compression force reduces, and has higher trackability, thus is easier to maneuver through tort...

    Woong Gil Choi, Seung Woon Rha, Cheol Ung Choi, Eung Ju Kim, Dong Joo Oh in Trials (2016)

  20. Article

    Open Access

    Efficacy of acupuncture for chronic asthma: study protocol for a randomized controlled trial

    Although asthma symptoms can be temporarily controlled, it is recommended to use effective low-risk, non-drug strategies to constitute a significant advance in asthma management. Acupuncture has been tradition...

    Lei-Miao Yin, Yu Wang, Lei Fan, Yu-Dong Xu, Wen-Qian Wang, Yan-Yan Liu in Trials (2015)

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