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Open AccessMsx1 and Msx2are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium
Msx1 and Msx2, which belong to the highly conserved Nk family of homeobox genes, display overlap** expression patterns and redundant functions in multiple tissues and organs during vertebrate development. Msx1 ...
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Article
Open AccessPrevalence of associated injuries of spinal trauma and their effect on medical utilization among hospitalized adult subjects – a nationwide data-based study
This study was wanted to investigate the prevalence of concomitant injuries among hospitalized acute spinal trauma patients aged 20 and over and the effects of those injuries on medical utilization in Taiwan.
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Article
Open AccessStructural and functional characterization of human apolipoprotein E 72-166 peptides in both aqueous and lipid environments
There are three apolipoprotein E (apoE) isoforms involved in human lipid homeostasis. In the present study, truncated apoE2-, apoE3- and apoE4-(72-166) peptides that are tailored to lack domain interactions ar...
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Article
Open AccessTreatment incidence of and medical utilization for hospitalized subjects with pathologic fractures in Taiwan-Survey of the 2008 National Health Insurance data
Almost all studies of pathologic fractures have been conducted based on patients with tumours and hospital-based data; however, in the present study, a nationwide epidemiological survey of pathologic fractures...
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Open AccessEpidemiological survey of orthopedic joint dislocations based on nationwide insurance data in Taiwan, 2000-2005
The epidemiology of acute orthopedic dislocations is poorly understood. A nationwide database provides a valuable resource for examining this issue in the Taiwanese population.
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Article
Open AccessSome properties of meromorphically multivalent functions
By using the method of differential subordinations, we derive certain properties of meromorphically multivalent functions.
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Article
Open AccessTumorigenesis role and clinical significance of DJ-1, a negative regulator of PTEN, in supraglottic squamous cell carcinoma
DJ-1 can induce the tumor cell proliferation and invasion via down-regulating PTEN in many malignant tumors, and correlated to prognostic significance. However, the tumorigenesis role and clinical significance...
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Article
Open AccessHirsutella sinensis mycelium suppresses interleukin-1β and interleukin-18 secretion by inhibiting both canonical and non-canonical inflammasomes
Cordyceps sinensis is a medicinal mushroom used for centuries in Asian countries as a health supplement and tonic. Hirsutella sinensis—the anamorphic, mycelial form of C. sinensis—possesses similar properties and...
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Article
Open AccessComparisons of medical utilizations and categorical diagnoses of emergency visits between the elderly with catastrophic illness certificates and those without
In Taiwan, the policy of catastrophic illness certificates has benefited some populations with specific diseases, but its effect on the use of medical services and the sequence of public health has not been ex...
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Article
Open AccessPrevalence of metabolic syndrome among urban community residents in China
Metabolic risk factors and abnormalities such as obesity and hypertension are rapidly rising among the Chinese population following China’s tremendous economic growth and widespread westernization of lifestyle...
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Article
Detection of multiple muscle involvement in eosinophilic myositis with 18F-FDG PET/CT
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Article
Open AccessThe association of metabolic syndrome and its factors with gallstone disease
To investigate the association between metabolic syndrome, including its factors, and gallstone disease (GSD) in a Taiwanese population.
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Article
Open AccessPromoter hypermethylation and silencing of tissue factor pathway inhibitor-2 in oral squamous cell carcinoma
The treatment of oral squamous cell carcinoma (OSCC) following early detection is associated with good outcomes. Therefore, the survival and prognosis of OSCC patients could be hugely improved by identifying r...
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Article
Open AccessThe role of Sequence Type (ST) 131 in adult community-onset non-ESBL-producing Escherichia colibacteraemia
To compare the epidemiological and clinical features and outcome in clonal group O25b/ST131 and non-clonal group O25b/ST131 in adult patients with non-extended-spectrum B-lactamase (ESBL)-producing Escherichia co...
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Article
Open AccessHypermethylation of the TGF-β target, ABCA1 is associated with poor prognosis in ovarian cancer patients
The dysregulation of transforming growth factor-β (TGF-β) signaling plays a crucial role in ovarian carcinogenesis and in maintaining cancer stem cell properties. Classified as a member of the ATP-binding cass...
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Article
Open AccessEmergence of differentially regulated pathways associated with the development of regional specificity in chicken skin
Regional specificity allows different skin regions to exhibit different characteristics, enabling complementary functions to make effective use of the integumentary surface. Chickens exhibit a high degree of r...
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Article
Open AccessTIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway
Previous study revealed that the protective effect of TIGAR in cell survival is mediated through the increase in PPP (pentose phosphate pathway) flux. However, it remains unexplored if TIGAR plays an important...
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Article
Open AccessEmergency visits among end-of-life cancer patients in Taiwan: a nationwide population-based study
An increased number of emergency visits at the end of life may indicate poor-quality cancer care. The study aimed to investigate the prevalence and utilization of emergency visits and to explore the reasons fo...
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Article
Does Patient Race/Ethnicity Influence Physician Decision-Making for Diagnosis and Treatment of Childhood Disruptive Behavior Problems?
Race/ethnic disparities in utilization of children’s mental health care have been well documented and are particularly concerning given the long-term risks of untreated mental health problems (Institute of Med...
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Article
Open AccessGenome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis
The identification of small molecules that target specific CFTR variants has ushered in a new era of treatment for cystic fibrosis (CF), yet optimal, individualized treatment of CF will require identification and...
