-
Article
Open AccessCRISPR-Cas and CRISPR-based screening system for precise gene editing and targeted cancer therapy
Target cancer therapy has been developed for clinical cancer treatment based on the discovery of CRISPR (clustered regularly interspaced short palindromic repeat) -Cas system. This forefront and cutting-edge s...
-
Article
Experimental Study on Gas–Water Seepage in High-Rank Coal and Its Research Significance
The gas–water seepage parameters of coal reservoir have to do with the development effect of coalbed methane (CBM) wells, and determine the output characteristics of fluid in coal. The gas–water seepage parame...
-
Article
Open AccessDesign and evaluation of blended teaching in the smart classroom combined with virtual simulation training in basic nursing courses
This study explored the application effect of smart classrooms combined with virtual simulation training in basic nursing courses for nursing undergraduates.
-
Article
Open AccessThe mediating effects of self-directed learning ability and critical thinking ability on the relationship between learning engagement and problem-solving ability among nursing students in Southern China: a cross-sectional study
Problem-solving ability has been identified as a core competence that nursing students should develop, and it plays a vital role in career development. Therefore, it is necessary to investigate factors related...
-
Article
Open AccessDefinitive Endodermal Cells Supply an in vitro Source of Mesenchymal Stem/Stromal Cells
Mesenchymal stem/Stromal cells (MSCs) have great therapeutic potentials, and they have been isolated from various tissues and organs including definitive endoderm (DE) organs, such as the lung, liver and intes...
-
Article
Open AccessEffectiveness of self-efficacy-enhancing interventions on rehabilitation following total hip replacement: a randomized controlled trial with six-month follow-up
As the world’s population ages, hip replacement, a routine treatment for arthritis, has become more common. However, after surgery, rehabilitation has some limited effectiveness with postoperative complication...
-
Article
Factors associated with returning to work and work ability of colorectal cancer survivors
The objective of this current study was to describe the status of returning to work and work ability of colorectal cancer survivors and identify the key factors associated with returning to work and work abili...
-
Article
Open AccessObstacles to access to community care in urban senior-only households: a qualitative study
The increased number of older adults living alone has created a substantial care need. However, the utilization rate of services and facilities to meet these needs are surprisingly low. Many of older adults ex...
-
Article
Open AccessA self-efficacy-enhancing intervention for Chinese patients after total hip arthroplasty: study protocol for a randomized controlled trial with 6-month follow-up
Total hip arthroplasty (THA) is a common and effective surgical method for advanced hip arthritis. Rehabilitation exercises are important to improve joint function after THA and are usually conducted in a home...
-
Article
Open AccessNicotinamide promotes cardiomyocyte derivation and survival through kinase inhibition in human pluripotent stem cells
Nicotinamide, the amide form of Vitamin B3, is a common nutrient supplement that plays important role in human fetal development. Nicotinamide has been widely used in clinical treatments, including the treatme...
-
Article
A correlation-breaking interleaving of polar codes in concatenated systems
-
Article
Open AccessNicotinamide promotes pancreatic differentiation through the dual inhibition of CK1 and ROCK kinases in human embryonic stem cells
Vitamin B3 (nicotinamide) plays important roles in metabolism as well as in SIRT and PARP pathways. It is also recently reported as a novel kinase inhibitor with multiple targets. Nicotinamide promotes pancrea...
-
Article
Total and denitrifying bacterial communities associated with the interception of nitrate leaching by carbon amendment in the subsoil
Nitrate leaching is severe in greenhouse where excessive nitrogen is often applied to maintain high crop productivities. In this study, we investigated the effects of carbon amendment in the subsoil on nitrate...
-
Article
Open AccessTargeting B7-H3 via chimeric antigen receptor T cells and bispecific killer cell engagers augments antitumor response of cytotoxic lymphocytes
B7-H3, an immune-checkpoint molecule and a transmembrane protein, is overexpressed in non-small cell lung cancer (NSCLC), making it an attractive therapeutic target. Here, we aimed to systematically evaluate t...
-
Article
Forecasting Short-Term Oil Price with a Generalised Pattern Matching Model Based on Empirical Genetic Algorithm
Price is an important guideline for measuring the changes in the oil market. Therefore, the forecasting of oil prices has become an important issue in oil market research. One of the problems, however, is that...
-
Article
Topological quantum walks in cavity-based quantum networks
We present a protocol to implement discrete-time quantum walks and simulate topological insulator phases in cavity-based quantum networks, where a single photon is the quantum walker and multiple cavity input–...
-
Article
Open AccessPACT/RAX Regulates the Migration of Cerebellar Granule Neurons in the Develo** Cerebellum
PACT and its murine ortholog RAX were originally identified as a protein activator for the dsRNA-dependent, interferon-inducible protein kinase PKR. Recent studies indicated that RAX played a role in embryogen...
-
Article
Open AccessAutophagy is involved in oligodendroglial precursor-mediated clearance of amyloid peptide
Accumulation of β-amyloid peptides is an important hallmark of Alzheimer’s disease (AD). Tremendous efforts have been directed to elucidate the mechanisms of β-amyloid peptides degradation and develop strategi...
-
Article
The effect of malformed tiles on tile assemblies within the kinetic tile assembly model
Many different constructions of proofreading tile sets have been proposed in the literature to reduce the effect of deviations from ideal behaviour of the dynamics of the molecular tile self-assembly process. ...
-
Article
Heat-transfer and solidification model of continuous slab casting: CON1D
A simple, but comprehensive model of heat transfer and solidification of the continuous casting of steel slabs is described, including phenomena in the mold and spray regions. The model includes a one-dimensio...
