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  1. No Access

    Article

    In vivo delivery of interferon-α gene enhances tumor immunity and suppresses immunotolerance in reconstituted lymphopenic hosts

    T cells recognize tumor-associated antigens under the condition of lymphopenia-induced homeostatic proliferation (HP); however, HP-driven antitumor responses gradually decay in association with tumor growth. T...

    K Narumi, T Udagawa, A Kondoh, A Kobayashi, H Hara, Y Ikarashi, S Ohnami… in Gene Therapy (2012)

  2. Article

    Streptozotocin-induced partial beta cell depletion in nude mice without hyperglycaemia induces pancreatic morphogenesis in transplanted embryonic stem cells

    It appears that the adult pancreas has limited regenerative ability following beta cell destruction by streptozotocin (STZ). However, it is not clear if this limitation is due to an inability to respond to, ra...

    F. Takeshita, M. Kodama, H. Yamamoto, Y. Ikarashi, S. Ueda, T. Teratani… in Diabetologia (2006)

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  3. Article

    Open Access

    Adenovirus-mediated interferon α gene transfer induces regional direct cytotoxicity and possible systemic immunity against pancreatic cancer

    We previously demonstrated a characteristically high sensitivity of pancreatic cancer cells to interferon alpha (IFN-α) gene transfer, which induced a more prominent growth suppression and cell death in pancreati...

    M Ohashi, K Yoshida, M Kushida, Y Miura, S Ohnami, Y Ikarashi… in British Journal of Cancer (2005)

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  4. Article

    Open Access

    Induction of vasculogenesis in breast cancer models

    Recently, there have been reports of postnatal vasculogenesis in cases of ischaemia models. The aim of the present study is to provide evidence of postnatal vasculogenesis in breast-cancer–bearing mice. Based ...

    K Shirakawa, S Furuhata, I Watanabe, H Hayase, A Shimizu… in British Journal of Cancer (2002)

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  5. No Access

    Article

    Effects of subacutely administered saiboku-to, an oriental herbal medicine, on pharmacodynamics and pharmacokinetics of diazepam in rodents

    Subacute treatment with saiboku-to (2000 mg/kg, p.o., once a day) for 7 days induced an anxiolytic-like effect in rats. It did not, however, produce any other effects, such as sedative and hypnotic effects, an...

    M. Yuzurihara, Y. Ikarashi, K. Ishihara… in European Journal of Drug Metabolism and Ph… (2000)

  6. No Access

    Article

    Age-hardening and formation of modulated structures in austenitic Fe-Mn-Al-C alloys

    Y. Ikarashi, K. Sato, T. Yamazaki, Y. Inoue… in Journal of Materials Science Letters (1992)