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    Article

    Hyperoside attenuates pyrrolizidine alkaloids-induced liver injury by ameliorating TFEB-mediated mitochondrial dysfunction

    Pyrrolizidine alkaloids (PAs) are potent hepatotoxins that can cause liver damage. Hyperoside (Hyp), a natural flavonoid, can be extracted from medicinal plants. Hyp displays hepatoprotective activity in vario...

    Jie Xu, Aizhen **ong, Xunjiang Wang, **ng Yan, Yilin Chen… in Archives of Pharmacal Research (2023)

  2. Article

    Open Access

    A TMT-based shotgun proteomics uncovers overexpression of thrombospondin 1 as a contributor in pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome

    Hepatic sinusoidal obstruction disease (HSOS) is a rare but life-threatening vascular liver disease. However, its underlying mechanism and molecular changes in HSOS are largely unknown, thus greatly hindering ...

    Weiqian Wang, Yan Chen, Yue Yin, Xunjiang Wang, Xuanling Ye… in Archives of Toxicology (2022)

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