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  1. No Access

    Article

    A Minimal PBPK Model for Plasma and Cerebrospinal Fluid Pharmacokinetics of Trastuzumab after Intracerebroventricular Administration in Patients with HER2-Positive Brain Metastatic Localizations

    Dosing regimens of trastuzumab administered by intracerebroventricular (icv) route to patients with HER2-positive brain localizations remain empirical. The objectives of this study were to describe pharmacokin...

    Alicja Puszkiel, Guilhem Bousquet, Françoise Stanke-Labesque… in Pharmaceutical Research (2023)

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    Article

    Accelerating robust plausible virtual patient cohort generation by substituting ODE simulations with parameter space map**

    The generation of plausible virtual patients (VPs) is an important step in most quantitative systems pharmacology (QSP) workflows, which requires time-intensive solving of ordinary differential equations (ODEs...

    Thibaud Derippe, Sylvain Fouliard… in Journal of Pharmacokinetics and Pharmacody… (2022)

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    Article

    Double or Simple Emulsion Process to Encapsulate Hydrophilic Oxytocin Peptide in PLA-PEG Nanoparticles

    Oral drug delivery using NPs is a current strategy for poorly absorbed molecules. It offers significant improvement in terms of bioavailability. However, the encapsulation of proteins and peptides in polymeric...

    Betty Gourdon, Xavier Declèves, Jean-Manuel Péan… in Pharmaceutical Research (2018)

  4. No Access

    Article

    Effect of Long-term In Vitro Lithium Exposure on mRNA Levels of Claudin-3, CYP1A1, ABCG2 and GSTM3 Genes in the hCMEC/D3 Human Brain Endothelial Cell Line

    Lithium chloride (LiCl) has been shown to improve the tightness of brain endothelial cell monolayers in vitro by inhibition of the GSK-3β enzyme, activation of the Wnt/beta-catenin pathway and regulation of ti...

    Ramzi Shawahna, Kayathiri Ganeshamoorthy… in European Journal of Drug Metabolism and Ph… (2017)

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    Article

    Physiologically Based Pharmacokinetic Modelling of Drug Penetration Across the Blood–Brain Barrier—Towards a Mechanistic IVIVE-Based Approach

    Predicting the penetration of drugs across the human blood–brain barrier (BBB) is a significant challenge during their development. A variety of in vitro systems representing the BBB have been described, but the ...

    Kathryn Ball, François Bouzom, Jean-Michel Scherrmann, Bernard Walther… in The AAPS Journal (2013)

  6. No Access

    Article

    P-Glycoprotein Is More Efficient at Limiting Uptake than Inducing Efflux of Colchicine and Vinblastine in HL-60 Cells

    Purpose. To investigate the role of the P-glycoprotein (P-gp) drug efflux pump in the intracellular disposition of colchicine and vinblastine.

    Xavier Declèves, Olivier Chappey, Bernadette Boval… in Pharmaceutical Research (1998)