5 Result(s)
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Article
Open AccessAdipose Tissue Formation Utilizing Fat Flap Distraction Technique
Co-regulation between adipocytes and supporting vasculature is considered an important process in adipose tissue generation. The objective of this study was to evaluate the mechanical and biological effects of...
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Article
Open AccessMortalin deficiency suppresses fibrosis and induces apoptosis in keloid spheroids
Mortalin (Mot) is a mitochondrial chaperone of the heat shock protein 70 family and it’s pro-proliferative and anti-apoptosis functions could be associated with keloid pathogenesis, and blocking of mortalin an...
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Article
Open AccessDecoy Wnt receptor (sLRP6E1E2)-expressing adenovirus induces anti-fibrotic effect via inhibition of Wnt and TGF-β signaling
Aberrant activation of the canonical Wingless type (Wnt) signaling pathway plays a key role in the development of hypertrophic scars and keloids, and this aberrant activation of Wnt pathway can be a potential ...
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Article
Open AccessProfibrogenic effect of high-mobility group box protein-1 in human dermal fibroblasts and its excess in keloid tissues
High-mobility group box 1 (HMGB1) protein acts as a DNA chaperone for nuclear homeostasis. It translocates into the cytosol and is secreted into extracellular spaces, triggering proinflammatory cytokines and a...
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Article
Open AccessInhibition of Wnt signaling pathway suppresses radiation-induced dermal fibrosis
Progressive fibrosis of the dermal tissues is a challenging complication of radiotherapy whose underlying mechanism is not fully understood, and there are few available treatments. The canonical Wnt/β-catenin ...
