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Article
Open AccessTargeted profiling of human extrachromosomal DNA by CRISPR-CATCH
Extrachromosomal DNA (ecDNA) is a common mode of oncogene amplification but is challenging to analyze. Here, we adapt CRISPR-CATCH, in vitro CRISPR-Cas9 treatment and pulsed field gel electrophoresis of agaros...
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Article
Open AccessSingle-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer
To chart cell composition and cell state changes that occur during the transformation of healthy colon to precancerous adenomas to colorectal cancer (CRC), we generated single-cell chromatin accessibility prof...
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Article
Open AccessAuthor Correction: ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis
A Correction to this paper has been published: https://doi.org/10.1038/s41588-021-00850-x.
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Article
Open AccessTranscription-dependent domain-scale three-dimensional genome organization in the dinoflagellate Breviolum minutum
Dinoflagellate chromosomes represent a unique evolutionary experiment, as they exist in a permanently condensed, liquid crystalline state; are not packaged by histones; and contain genes organized into tandem ...
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Article
Open AccessArchR is a scalable software package for integrative single-cell chromatin accessibility analysis
The advent of single-cell chromatin accessibility profiling has accelerated the ability to map gene regulatory landscapes but has outpaced the development of scalable software to rapidly extract biological mea...
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Article
Correction: Corrigendum: Landscape of monoallelic DNA accessibility in mouse embryonic stem cells and neural progenitor cells
Nat. Genet.; 10.1038/ng.3769; corrected online 13 February 2017 In the version of this article initially published online, there were two errors. In the section “Three classes of monoallelic elements” in the m...