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  1. No Access

    Article

    Tannic Acid Impedes the Proliferation of Bladder Cancer Cells by Elevating Mitochondrial Pathways of Apoptosis

    Bladder cancer stands as a prevailing neoplasm among men globally, distinguished for its pronounced malignancy attributed to invasiveness and metastatic proclivity. Tannic acid (TA), an organic compound in man...

    Chi-Cheng Li, Bruce Chi-Kang Tsai… in Cell Biochemistry and Biophysics (2024)

  2. Article

    Open Access

    CircMAST1 inhibits cervical cancer progression by hindering the N4-acetylcytidine modification of YAP mRNA

    Cervical cancer (CCa) is the fourth most common cancer among females, with high incidence and mortality rates. Circular RNAs (circRNAs) are key regulators of various biological processes in cancer. However, th...

    Chunyu Zhang, Li Yuan, Qiaojian Zou, Caixia Shao… in Cellular & Molecular Biology Letters (2024)

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  3. Article

    Open Access

    HIF-1α/JMJD1A signaling regulates inflammation and oxidative stress following hyperglycemia and hypoxia-induced vascular cell injury

    Endothelial cell (EC) injury accelerates the progression of diabetic macrovascular complications. Hypoxia is an important cause of EC injury. Hypoxia-inducible factor-1 alpha (HIF-1α) is an important hypoxia r...

    Min Zhao, Shaoting Wang, Anna Zuo, Jiaxing Zhang… in Cellular & Molecular Biology Letters (2021)

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  4. No Access

    Article

    Development and validation of high-throughput and low-cost STARP assays for genes underpinning economically important traits in wheat

    We developed and validated 56 gene-specific semi-thermal asymmetric reverse PCR (STARP) markers for 46 genes of important wheat quality, biotic and abiotic stress resistance, grain yield, and adaptation-relate...

    Yuying Wu, Ming Li, Zhonghu He, Susanne Dreisigacker… in Theoretical and Applied Genetics (2020)

  5. No Access

    Article

    Genetic dissection of a major QTL for kernel weight spanning the Rht-B1 locus in bread wheat

    Genetic dissection uncovered a major QTL QTKW.caas-4BS corresponding with a 483 kb deletion that included genes ZnF, EamA and Rht-B1. This deletion was associated with increased grain weight and semi-dwarf phenot...

    Dengan Xu, Weie Wen, Lu** Fu, Faji Li, Jihu Li… in Theoretical and Applied Genetics (2019)

  6. No Access

    Article

    Genome-wide variation patterns between landraces and cultivars uncover divergent selection during modern wheat breeding

    Genetic diversity, population structure, LD decay, and selective sweeps in 687 wheat accessions were analyzed, providing relevant guidelines to facilitate the use of the germplasm in wheat breeding.

    **dong Liu, Awais Rasheed, Zhonghu He, Muhammad Imtiaz… in Theoretical and Applied Genetics (2019)

  7. No Access

    Article

    Genome-wide linkage map** of yield-related traits in three Chinese bread wheat populations using high-density SNP markers

    We identified 21 new and stable QTL, and 11 QTL clusters for yield-related traits in three bread wheat populations using the wheat 90 K SNP assay.

    Faji Li, Weie Wen, Zhonghu He, **dong Liu, Hui **… in Theoretical and Applied Genetics (2018)

  8. No Access

    Article

    Genome-wide linkage map** of QTL for black point reaction in bread wheat (Triticum aestivum L.)

    Nine QTL for black point resistance in wheat were identified using a RIL population derived from a Linmai 2/Zhong 892 cross and 90K SNP assay.

    **dong Liu, Zhonghu He, Ling Wu, Bin Bai, Weie Wen… in Theoretical and Applied Genetics (2016)

  9. No Access

    Article

    Development and validation of KASP assays for genes underpinning key economic traits in bread wheat

    We developed and validated a robust marker toolkit for high-throughput and cost-effective screening of a large number of functional genes in wheat.

    Awais Rasheed, Weie Wen, Fengmei Gao, Shengnan Zhai… in Theoretical and Applied Genetics (2016)

  10. No Access

    Article

    Cloning of TaSST genes associated with water soluble carbohydrate content in bread wheat stems and development of a functional marker

    We cloned TaSST genes, developed a gene-specific marker for TaSST - D1 , and identifi...

    Yan Dong, Yan Zhang, Yonggui **ao, Jun Yan, **dong Liu… in Theoretical and Applied Genetics (2016)

  11. No Access

    Article

    Genome-wide linkage map** of flour color-related traits and polyphenol oxidase activity in common wheat

    Fifty-six QTL for flour color-related traits and polyphenol oxidase activity were identified using a genome-wide linkage map** of data from a RIL population derived from a Gaocheng 8901/Zhoum...

    Shengnan Zhai, Zhonghu He, Weie Wen, Hui **… in Theoretical and Applied Genetics (2016)

  12. No Access

    Article

    Map** quantitative trait loci for peroxidase activity and develo** gene-specific markers for TaPod-A1 on wheat chromosome 3AL

    Three novel QTL for peroxidase activity were mapped, and gene-specific markers for TaPod-A1 were developed and validated using RILs derived from the Doumai/Shi 4185 cross and ...

    **gxin Wei, Hongwei Geng, Yan Zhang, **dong Liu… in Theoretical and Applied Genetics (2015)

  13. No Access

    Article

    Enhancement of vindoline and vinblastine production in suspension-cultured cells of Catharanthus roseus by artemisinic acid elicitation

    Elicitation is an important strategy to improve production of secondary metabolites in vitro. Artemisinic acid was studied as a novel elicitor to enhance the yield of terpenoid indole alkaloids in the present ...

    **wei Liu, Jianhua Zhu, Le Tang, Wei Wen… in World Journal of Microbiology and Biotechn… (2014)

  14. No Access

    Article

    Population structure and association map** on chromosome 7 using a diverse panel of Chinese germplasm of rice (Oryza sativa L.)

    The majority of 170 rice accessions used in this study were diverse landraces or varieties from a putative mini-core collection of Chinese germplasm along with some widely used parental lines in genetic analys...

    Weiwei Wen, Hanwei Mei, Fangjun Feng, Sibin Yu… in Theoretical and Applied Genetics (2009)

  15. No Access

    Article

    Rosmarinic acid production in perfused Anchusa officinalis culture: Effect of inoculum size

    High cell density and rosmarinic acid (RA) productivity have been achieved by applying periodic culture perfusion to the Anchusa officinalis cell suspension. In this study, the effect of inoculum size on cell gro...

    Wei Wen Su, Fei Lei in Biotechnology Letters (1993)

  16. No Access

    Article

    Production of rosmarinic acid from perfusion culture ofAnchusa officinalis in a membrane-aerated bioreactor

    In this study, a perfusion fermentation ofAnchusa officinalis was carried out in a stirred tank bioreactor integrated with an internal cross-flow filter. Bubble-free aeration via microporous membrane fibers was u...

    Wei Wen Su, Arthur E. Humphrey in Biotechnology Letters (1991)

  17. No Access

    Article

    Production of rosmarinic acid in high density perfusion cultures ofAnchusa officinalis using a high sugar medium

    The most direct approach to enhancing the volumetric yield of secondary metabolites in plant tissue cultures is to operate the culture under high cell density. In this study, a cell suspension ofAnchusa officinal...

    Wei-Wen Su, Arthur E. Humphrey in Biotechnology Letters (1990)