19 Result(s)
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Article
W. E. Müller
Medicine & Public Health
Psychiatry
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Article
1H- and 13C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer’s disease
Biochemical alterations underlying the symptoms and pathomechanisms of Alzheimer’s disease (AD) are not fully understood. However, alterations of glucose metabolism and mitochondrial dysfunction certainly play...
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Efficacy of St. John’s wort extract WS® 5570 in acute treatment of mild depression
Based on the original data from two double-blind, randomized, placebo-controlled clinical trials and the acute phase of a long-term study that investigated the antidepressant efficacy of St. John’s wort extrac...
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Apolipoprotein E epsilon 4 is associated with an increased vulnerability to cell death in Alzheimer’s disease
The presumption to suffer from Alzheimer’s disease (AD) accelerates with aging. One important risk factor seems to be the isoform epsilon 4 of the apolipoprotein E gene (Apo ɛ4), which increases the risk to de...
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Statins: drugs for Alzheimer’s disease?
Evidences from cell culture experiments and animal studies suggest a strong link between cholesterol and Alzheimer’s disease (AD). This relationship is supported by retrospective epidemiological studies demons...
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Impact of gender on upregulation of antioxidant defence mechanisms in Alzheimer’s disease brain
Since oxidative stress plays an important role in the pathogenesis of Alzheimer’s disease (AD) and since the age-adjusted incidence of AD is higher in females than males, we examined a possible influence of ge...
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Specific modulation of sigma binding sites by the anxiolytic drug opipramol
The atypical anxiolytic and antidepressive drug opipramol binds with high affinity to σ1 and somewhat lower affinity to σ2 sites. After subchronic treatment, opipramol significantly down-regulated σ2 but not σ1 ...
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Age-related increase of oxidative stress-induced apoptosis in micePrevention by Ginkgo biloba extract (EGb761)
Enhanced apoptosis and elevated levels of reactive oxygen species (ROS) play a major role in aging. In addition, several neurodegenerative diseases are associated with increased oxidative stress and apoptosis...
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ROS generation, lipid peroxidation and antioxidant enzyme activities in the aging brain
The objective of this study was to determine the specific relationship between brain aging and changes in the level of oxidative stress, lipid peroxidation (LPO) and in the activities of antioxidant enzymes. ...
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Effects of aging and β-amyloid on the properties of brain synaptic and mitochondrial membranes
The effects of aging and of different amyloid β-peptides (Aβ) on the properties of purified synaptosomal plasma and mitochondrial membranes were studied using different fluorescent dyes. Aging led to opposite...
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Subchronic treatment with prazosin improves passive avoidance learning in aged mice: possible relationships to α1-receptor up-regulation
While many evidences indicate that deficits of central noradrenergic neurotransmission are involved in the age-related decline of cognitive functions in animals and man, very little is known about the specifi...
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Piracetam reverses hippocampal membrane alterations in Alzheimer's disease
The in vitro effects of piracetam treatment on the fluidity of membranes from the hippocampus of Alzheimer's Disease patients (AD) and non-demented controls were studied. Hippocampal membranes of AD patients sho...
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Learning abilities depend on NMDA-receptor density in hippocampus in adult rats
The hippocampal NMDA-receptor is predominantly involved to establish long-term potentation (LTP) which is assumed to underlie fundamental molecular mechanisms of learning and memory. In the present study, NMDA...
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Abstracts Second Congress of the European Society for Clinical Neuropharmacology
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Platelet and lymphocyte free intracellular calcium in affective disorders
Many studies have demonstrated pharmacologic similarities between platelet and brain 5-HT2 binding sites. Therefore it may be possible to use platelets as a model for the central serotonergic neuron. Accordingly,...
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Levoprotiline ((−)-oxaprotiline) effects on inositol phosphate generation in human peripheral lymphocytes
The effects of the atypical antidepressant levoprotiline (LPT) on inositol phosphate metabolism were investigated in N-formyl-methionyl-leucylphenylalanine (fMLP) activated human lymphocytes. In the presence o...
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Specific decrease of high-affinity agonist states of alpha2-adrenoceptors in the aging mouse brain
Using the specific binding of the full alpha2-adrenergic agonist3H-UK-14,304 the contribution of high-affinity agonist states to the total number of alpha2-adrenoceptors as labeled by the specific binding of the ...
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Chronic treatment with choline or scopolamine indicates the presence of muscarinic cholinergic receptor plasticity in the frontal cortex of young but not of aged mice
Chronic treatment (2 weeks) with either scopolamine (4 mg/kg, once daily p.o.) or choline (200 mg/kg, once daily p.o.) resulted in a pronounced muscarinic cholinergic receptor up- or down-regulation in the fro...
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Stereospecific3H-QNB binding to human erythrocyte membranes associated with muscarinic cholinergic receptors
Specific binding of the muscarinic antagonist3H-QNB can be demonstrated on human erythrocyte membranes. Specific3H-QNB binding is stereospecific and can be inhibited by a variety of cholinergic agonists and antag...
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Peripheral benzodiazepine binding sites on striated muscles of the rat: Properties and effect of denervation
In order to test the hypothesis that peripheral benzodiazepine binding sites mediate some direct effects of benzodiazepines on striated muscles, the properties of specific3H-Ro 5-4864 binding to rat biceps and ra...
