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Article
Urinary metabolites of amitriptylinoxide and amitriptyline in single-dose experiments and during continuous therapy
In a cross-over design, six healthy volunteers received 50 mg amitriptylinoxide (AT-NO) IV and orally and 50 mg amitriptyline (AT) IV. Urine was collected completely for 8 h and occasionally up to 48 h. In add...
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Article
Therapeutic concentrations of lithium and carbamazepine inhibit cGMP accumulation in human lymphocytes
Although a large variety of biochemical effects have been reported for lithium (Li) and carbamazepine (Cbm), the final molecular mechanism underlying their therapeutic efficacy for recurrent affective disorder...
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Article
Piracetam elevates muscarinic cholinergic receptor density in the frontal cortex of aged but not of young mice
Chronic treatment (2 weeks) with piracetam (500 mg/kg, once daily PO) elevatedm-cholinoceptor density in the frontal cortex of aged (18 months) female mice by about 30–40%, but had no effect onm-cholinoceptor den...