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  1. No Access

    Article

    Target identification and mechanism of action in chemical biology and drug discovery

    Target-identification and mechanism-of-action studies have important roles in small-molecule probe and drug discovery. Biological and technological advances have resulted in the increasing use of cell-based as...

    Monica Schenone, Vlado Dančík, Bridget K Wagner, Paul A Clemons in Nature Chemical Biology (2013)

  2. No Access

    Article

    Correlating chemical sensitivity and basal gene expression reveals mechanism of action

    A computational tool provides a systematic approach to determine the mechanisms of action of small molecules by examining correlations between basal gene expression and small-molecule sensitivity in cancer cel...

    Matthew G Rees, Brinton Seashore-Ludlow, Jaime H Cheah… in Nature Chemical Biology (2016)

  3. Article

    Open Access

    A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

    Clear-cell carcinomas (CCCs) are a histological group of highly aggressive malignancies commonly originating in the kidney and ovary. CCCs are distinguished by aberrant lipid and glycogen accumulation and are ...

    Yilong Zou, Michael J. Palte, Amy A. Deik, Haoxin Li… in Nature Communications (2019)

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  4. Article

    Open Access

    High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases

    The development of site-specific recombinases (SSRs) as genome editing agents is limited by the difficulty of altering their native DNA specificities. Here we describe Rec-seq, a method for revealing the DNA s...

    Jeffrey L. Bessen, Lena K. Afeyan, Vlado Dančík, Luke W. Koblan… in Nature Communications (2019)

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  5. Article

    Open Access

    Addendum: High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases

    Jeffrey L. Bessen, Lena K. Afeyan, Vlado Dančík, Luke W. Koblan… in Nature Communications (2019)

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  6. No Access

    Article

    Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

    Ferroptosis—an iron-dependent, non-apoptotic cell death process—is involved in various degenerative diseases and represents a targetable susceptibility in certain cancers1. The ferroptosis-susceptible cell state ...

    Yilong Zou, Whitney S. Henry, Emily L. Ricq, Emily T. Graham… in Nature (2020)

  7. No Access

    Article

    A general approach to identify cell-permeable and synthetic anti-CRISPR small molecules

    The need to control the activity and fidelity of CRISPR-associated nucleases has resulted in a demand for inhibitory anti-CRISPR molecules. The small-molecule inhibitor discovery platforms available at present...

    Donghyun Lim, Qingxuan Zhou, Kurt J. Cox, Benjamin K. Law… in Nature Cell Biology (2022)