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Article
A Comparison of Estimation Methods for Shared Gamma Frailty Models
This paper compares six different estimation methods for shared frailty models via a series of simulation studies. A shared frailty model is a survival model that incorporates random effects, where the frailti...
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Article
Development of glucose/pH responsive smart hydrogel of carbopol and application in microneedles
A new glucose-responsive polymer made from carbopol and 3-phenylboronic acid was developed with condensation reaction. The resulting polymer possesses a pKa of 6.86 ± 0.38 at a proper feedstock ratio of 1:2 (w/w)...
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Article
Open AccessProtocol of a prospective and multicentre China Teratology Birth Cohort (CTBC): association of maternal drug exposure during pregnancy with adverse pregnancy outcomes
As reported, 27-93 % of pregnant women take at least one drug during pregnancy. However, drug exposure during pregnancy still lacks sufficient foetal safety evidence of human origin. It is urgent to fill the k...