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Article
Using 31P NMR Spectroscopy at 14.1 Tesla to Investigate PARP-1 Associated Energy Failure and Metabolic Rescue in Cerebrocortical Slices
PARP-1 activation by H2O2 in an acute preparation of superfused, respiring, neonatal cerebrocortical slices was assessed from PAR-polymer formation detected with immunohistochemistry and Western blotting. 31P NMR...
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Article
Identification of ligands for RNA targets via structure-based virtual screening: HIV-1 TAR
Binding of the Tat protein to TAR RNA is necessary for viral replication of HIV-1. We screened the Available Chemicals Directory (ACD) to identify ligands to bind to a TAR RNA structure using a four-step docki...
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Article
Structure-based design of ligands for protein basic domains: Application to the HIV-1 Tat protein
A methodology has been developed for designing ligands to bind a flexible basic protein domain where the structure of the domain is essentially known. It is based on an empirical binding free energy function d...