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    Article

    Using 31P NMR Spectroscopy at 14.1 Tesla to Investigate PARP-1 Associated Energy Failure and Metabolic Rescue in Cerebrocortical Slices

    PARP-1 activation by H2O2 in an acute preparation of superfused, respiring, neonatal cerebrocortical slices was assessed from PAR-polymer formation detected with immunohistochemistry and Western blotting. 31P NMR...

    Jianying Zeng, Kiyoshi Hirai, Guo-Yuan Yang… in Journal of Bioenergetics and Biomembranes (2004)

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    Article

    Identification of ligands for RNA targets via structure-based virtual screening: HIV-1 TAR

    Binding of the Tat protein to TAR RNA is necessary for viral replication of HIV-1. We screened the Available Chemicals Directory (ACD) to identify ligands to bind to a TAR RNA structure using a four-step docki...

    Anton V. Filikov, Venkatraman Mohan… in Journal of Computer-Aided Molecular Design (2000)

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    Article

    Structure-based design of ligands for protein basic domains: Application to the HIV-1 Tat protein

    A methodology has been developed for designing ligands to bind a flexible basic protein domain where the structure of the domain is essentially known. It is based on an empirical binding free energy function d...

    Anton V. Filikov, Thomas L. James in Journal of Computer-Aided Molecular Design (1998)