5 Result(s)
within
Article
Terri H Beaty
Life Sciences
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Article
Open AccessA genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry
Pulmonary function decline is a major contributor to morbidity and mortality among smokers. Post bronchodilator FEV1 and FEV1/FVC ratio are considered the standard assessment of airflow obstruction. We performed ...
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Article
Open AccessA colorectal cancer prediction model using traditional and genetic risk scores in Koreans
Genome-wide association studies have identified numerous single nucleotide polymorphisms (SNPs) as associated with colorectal cancer (CRC) risk in populations of European descent. However, their utility for pr...
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Article
Open AccessA genome-wide study of de novo deletions identifies a candidate locus for non-syndromic isolated cleft lip/palate risk
Copy number variants (CNVs) may play an important part in the development of common birth defects such as oral clefts, and individual patients with multiple birth defects (including clefts) have been shown to ...
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Open AccessFast detection of de novo copy number variants from SNP arrays for case-parent trios
In studies of case-parent trios, we define copy number variants (CNVs) in the offspring that differ from the parental copy numbers as de novo and of interest for their potential functional role in disease. Amo...
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Open AccessA graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q
Past work on asthmatic African American families revealed a strong linkage peak with modest evidence of association on chromosome 11q. Here, we perform tests of association for asthma and a panel of 609 SNPs i...
