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Article
Open AccessSystem analysis based on Anoikis-related genes identifies MAPK1 as a novel therapy target for osteosarcoma with neoadjuvant chemotherapy
Osteosarcoma (OS) is the most common bone malignant tumor in children, and its prognosis is often poor. Anoikis is a unique mode of cell death.However, the effects of Anoikis in OS remain unexplored.
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Article
Open AccessEnd-organ damage from neonatal invasive fungal infection: a 14-year retrospective study from a tertiary center in China
Invasive fungal infection (IFI) has become an increasing problem in NICU neonates, and end-organ damage (EOD) from IFI is one of the leading causes of morbidity and mortality in neonates. This study was conduc...
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Article
Open AccessThe Hippo-YAP signaling pathway drives CD24-mediated immune evasion in esophageal squamous cell carcinoma via macrophage phagocytosis
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies in the world with poor prognosis. Despite the promising applications of immunotherapy, the objective response rate is still unsa...
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Article
The value of an apparent diffusion coefficient histogram model in predicting meningioma recurrence
To investigate the predictive value of a model combining conventional MRI features and apparent diffusion coefficient (ADC) histogram parameters for meningioma recurrence.
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Article
Open AccessClinical features and prognosis of acute-on-chronic liver failure in patients with recompensated cirrhosis
There are few studies on acute-on-chronic liver failure (ACLF) in patients with recompensated cirrhosis. This study was aimed to investigate the clinical features of ACLF patients with recompensated cirrhosis.
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Article
Open AccessCharacteristics of acute kidney injury and its impact on outcome in patients with acute-on-chronic liver failure
Acute kidney injury (AKI) is a common and life-threatening complication of liver failure. The purpose of this study is to construct a nomogram and online calculator to predict the development of hospital-acqui...
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Article
Open AccessHepatitis B-related acute-on-chronic liver failure induced by hepatotropic viral insult is associated with worse prognosis than that induced by non-virus insult
The manifestations and prognoses of acute-on-chronic liver failure (ACLF) with different precipitating events remain heterogeneous. We aimed to investigate the characteristics and prognosis of patients with he...
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Article
Open AccessInvasive Pulmonary Aspergillosis in Acute-on-Chronic Liver Failure Patients: Short-Term Outcomes and Antifungal Options
Acute-on-chronic liver failure (ACLF) patients are susceptible to invasive fungal infections. We evaluated the prognosis and antifungal options in ACLF patients with invasive pulmonary aspergillosis (IPA).
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Article
Open AccessTolvaptan therapy of Chinese cirrhotic patients with ascites after insufficient diuretic routine medication responses: a phase III clinical trial
To determine the safety and efficacy of different doses of tolvaptan for treating Chinese cirrhotic patients with or without hyponatraemia who still had ascites after routine therapy with diuretics.
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Article
Open AccessAnalysis of the pharmacological mechanism of Banxia **exin decoction in treating depression and ulcerative colitis based on a biological network module
The network pharmacology method was used to predict the active components of Banxia **exin decoction, its targets and the key signalling pathways that are activated in the treatment of depression and ulcerativ...
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Article
Open AccessLiver cirrhosis in a patient with hepatic hereditary hemorrhagic telangiectasia and Budd–Chiari syndrome: a case report
Hereditary hemorrhagic telangiectasia (HHT) often involves the liver, and belongs to abnormal blood vessel disease. The etiology of Budd–Chiari syndrome (BCS) is not clear, but congenital vascular dysplasia is...
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Article
Open AccessA nationwide survey on neonatal medical resources in mainland China: current status and future challenges
With the rapid development of economy in recent two decades, neonatology has been progressing quickly in China. However, there is little knowledge about the exact developmental status of neonatal departments i...
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Article
Open AccessTolvaptan treatment improves survival of cirrhotic patients with ascites and hyponatremia
Although tolvaptan treatment improves hyponatremia, only few studies have investigated whether tolvaptan actually benefits the survival of cirrhotic patients. This study evaluated the impact of tolvaptan on si...
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Article
MiR-345 suppresses proliferation, migration and invasion by targeting Smad1 in human prostate cancer
The roles of dysregulated microRNAs in prostate cancer metastasis are still unknown. In this study, we found that the expression of miR-345 was significantly downregulated in prostate cancer and clinical prost...