8 Result(s)
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Article
Tao han
Life Sciences
Microarrays
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Article
Open AccessStatus of hepatic DNA methylome predetermines and modulates the severity of non-alcoholic fatty liver injury in mice
Nonalcoholic fatty liver disease (NAFLD) is a major health problem and a leading cause of chronic liver disease in the United States and Western countries. In humans, genetic factors greatly influence individu...
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Open AccessCharacterization of whole genome amplified (WGA) DNA for use in genoty** assay development
Genoty** assays often require substantial amounts of DNA. To overcome the problem of limiting amounts of available DNA, Whole Genome Amplification (WGA) methods have been developed. The multiple displacement...
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Open AccessAssessing batch effects of genotype calling algorithm BRLMM for the Affymetrix GeneChip Human Map** 500 K array set using 270 HapMap samples
Genome-wide association studies (GWAS) aim to identify genetic variants (usually single nucleotide polymorphisms [SNPs]) across the entire human genome that are associated with phenotypic traits such as diseas...
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Open AccessImprovement in the Reproducibility and Accuracy of DNA Microarray Quantification by Optimizing Hybridization Conditions
DNA microarrays, which have been increasingly used to monitor mRNA transcripts at a global level, can provide detailed insight into cellular processes involved in response to drugs and toxins. This is leading ...
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Open AccessMicroarray analysis distinguishes differential gene expression patterns from large and small colony Thymidine kinase mutants of L5178Y mouse lymphoma cells
The Thymidine kinase (Tk) mutants generated from the widely used L5178Y mouse lymphoma assay fall into two categories, small colony and large colony. Cells from the large colonies grow at a normal rate while cell...
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Open AccessMicroarray scanner calibration curves: characteristics and implications
Microarray-based measurement of mRNA abundance assumes a linear relationship between the fluorescence intensity and the dye concentration. In reality, however, the calibration curve can be nonlinear.
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Open AccessA microarray study of MPP+-treated PC12 Cells: Mechanisms of toxicity (MOT) analysis using bioinformatics tools
This paper describes a microarray study including data quality control, data analysis and the analysis of the mechanism of toxicity (MOT) induced by 1-methyl-4-phenylpyridinium (MPP+) in a rat adrenal pheochromoc...
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Open AccessCross-platform comparability of microarray technology: Intra-platform consistency and appropriate data analysis procedures are essential
The acceptance of microarray technology in regulatory decision-making is being challenged by the existence of various platforms and data analysis methods. A recent report (E. Marshall, Science, 306, 630–631, 2004...
