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  1. No Access

    Article

    Overexpression of SerpinB9 in non-seminomatous germ cell tumors

    Serpinb9 is an inhibitor of granzyme B and is potentially involved in the immune escape of tumor cells. In the present study, bioinformatics analysis using open databases suggested that SerpinB9 is overexpress...

    Toshiki Anami, Yuki Ibe, Lianbo Li, Yoshihiro Komohara… in Medical Molecular Morphology (2024)

  2. No Access

    Article

    High T-cell infiltration in tumor tissue and younger age predict the response to pembrolizumab in recurrent urothelial cancer

    Targeting the programmed cell death-1 signaling pathway has been approved for the anti-cancer therapy in several cancers including urothelial cancer. To determine predictive factors of the responsiveness to pe...

    Toshiki Anami, Yoshihiro Komohara, Yuji Miura… in Medical Molecular Morphology (2021)

  3. No Access

    Article

    CD163-positive cancer cells are potentially associated with high malignant potential in clear cell renal cell carcinoma

    CD163 is preferentially expressed by monocyte/macrophages; however, recent studies using immunohistochemistry (IHC) have reported that some cancer cells also express CD163. In the present IHC study, we investi...

    Chaoya Ma, Hasita Horlad, Koji Ohnishi, Takenobu Nakagawa… in Medical Molecular Morphology (2018)

  4. No Access

    Article

    Phenotypical change of tumor-associated macrophages in metastatic lesions of clear cell renal cell carcinoma

    Macrophages are the main immune cells of the tumor microenvironment in clear cell renal cell carcinoma (ccRCC). A high density of CD163+ or CD204+ tumor-associated macrophages (TAMs), rather than the density of t...

    Takanobu Motoshima, Yuji Miura, Nanako Wakigami… in Medical Molecular Morphology (2018)

  5. No Access

    Article

    The significance of TIMD4 expression in clear cell renal cell carcinoma

    T-cell immunoglobulin and mucin domain (TIMD) family genes are related to innate immune responses. TIMD4 is a receptor for phosphatidylserine and is involved in the phagocytosis of apoptotic cells by macrophag...

    Hiromu Yano, Takanobu Motoshima, Chaoya Ma, Cheng Pan… in Medical Molecular Morphology (2017)

  6. Article

    Open Access

    PD-L1 expression in papillary renal cell carcinoma

    The immune escape or tolerance of cancer cells is considered to be closely involved in cancer progression. Programmed death-1 (PD-1) is an inhibitory receptor expressed on activating T cells, and several types...

    Takanobu Motoshima, Yoshihiro Komohara, Chaoya Ma, Arni Kusuma Dewi… in BMC Urology (2017)

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