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Article
Co-transplantation of autologous Treg cells in a cell therapy for Parkinson’s disease
The specific loss of midbrain dopamine neurons (mDANs) causes major motor dysfunction in Parkinson’s disease, which makes cell replacement a promising therapeutic approach1–4. However, poor survival of grafted mD...
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Article
Open AccessChloroquine modulates inflammatory autoimmune responses through Nurr1 in autoimmune diseases
For over a half-century the anti-malarial drug chloroquine (CQ) has been used as a therapeutic agent, alone or in combination, to treat autoimmune diseases. However, neither the underlying mechanism(s) of acti...
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Article
Open AccessEngineering de novo disulfide bond in bacterial α-type carbonic anhydrase for thermostable carbon sequestration
Exploiting carbonic anhydrase (CA), an enzyme that rapidly catalyzes carbon dioxide hydration, is an attractive biomimetic route for carbon sequestration due to its environmental compatibility and potential ec...
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Article
Open AccessA stem-group cnidarian described from the mid-Cambrian of China and its significance for cnidarian evolution
Palaeontological data of extinct groups often sheds light on the evolutionary sequences leading to extant groups, but has failed to resolve the basal metazoan phylogeny including the origin of the Cnidaria. He...