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Article
Spontaneous large intra-abdominal wall haematoma as a rare complication in a maintenance haemodialysis patient
The incidence of spontaneous bleeding in various parts of the body has been reported to be high in patients receiving maintenance haemodialysis. We present a case of spontaneous large haematoma of the intra-ab...
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Article
Effect of betaine onS-adenosylmethionine levels in the cerebrospinal fluid in a patient with methylenetetrahydrofolate reductase deficiency and peripheral neuropathy
A 16-year-old Japanese girl with 5,10-methylenetetrahydrofolate reductase deficiency showed peripheral neuropathy. There were no significant responses to vitamin B6, vitamin B12 or folate, given alone or in combi...
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Article
Elevated plasma bile acids in hypergalactosaemic neonates: a diagnostic clue to portosystemic shunts
To determine whether plasma levels of total bile acids may provide a useful index for hypergalactosaemia due to porto-systemic shunts, these levels were determined in hypergalactosaemic neonates. Increased le...
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Article
RB silencing compromises the DNA damage-induced G2/M checkpoint and causes deregulated expression of the ECT2 oncogene
As alterations in retinoblastoma (RB)/E2F pathway are commonly found in human cancers, the molecular mechanism underlying cell cycle deregulation caused by the mutations in the RB/E2F pathway needs to be inves...
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Article
Attenuated radial augmentation index is associated with successful long-term antihypertensive treatment
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Article
HSF1 regulation of β-catenin in mammary cancer cells through control of HuR/elavL1 expression
There is now compelling evidence to indicate a place for heat shock factor 1 (HSF1) in mammary carcinogenesis, tumour progression and metastasis. Here we have investigated a role for HSF1 in regulating the exp...
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Article
Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis
Elevated levels of the inducible heat-shock protein 70 (Hsp72) have been implicated in mammary tumorigenesis in histological investigations of human breast cancer. We therefore examined the role of Hsp72 in mi...