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    Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration

    Lipid Nanoparticles (LNPs) are used to deliver siRNA and COVID-19 mRNA vaccines. The main factor known to determine their delivery efficiency is the pKa of the LNP containing an ionizable lipid. Herein, we rep...

    Manuel J. Carrasco, Suman Alishetty, Mohamad-Gabriel Alameh… in Communications Biology (2021)

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