6,211 Result(s)

Article

Effects of cytosine arabinoside on DNA synthesis and mitotic activity of HL-60 cells

HL-60 cells were exposed to tritiated thymidine (³HTdR) alone (control group), to cytosine arabinoside followed by³HTdR or to tritium labelled cytosine arabinoside (³H-AraC) for one hour followed by incubation wi...

A. Raza, S. C. Zhao, K. Kulizkowski… in Medical Oncology and Tumor Pharmacotherapy (1985)

Article

Comparison of autoradiography and DNA histograms in assessing S-phase cells from patients with myeloid leukemias

The studies reported here were designed to determine whether DNA histogram analysis provided the same estimate for the percentage of cells in S-phase as does³H-TdR labeling index (LI). For DNA histogram analysis ...

Azra Raza, Abbas S. Raza… in Medical Oncology and Tumor Pharmacotherapy (1985)

Article

Wikstroemia indica promotes development of nasopharyngeal carcinoma in rats initiated by dinitrosopiperazine

Nasopharyngeal carcinoma was induced in an initiation/promotion model in rats by s.c. injection of dinitrosopiperazine in the nasopharyngeal cavity. This was followed by repeated 10-cal administration of an ex...

W. P. Tang, P. G. Huang, M. L. Zhao… in Journal of Cancer Research and Clinical On… (1988)

Article

Preliminary result of mixed bacterial vaccine as adjuvant treatment of hepatocellular carcinoma

Mixed bacterial vaccine (MBV) was employed in the multi-modality treatment of hepatocellular carcinoma (HCC) during 1985–1988. Thirty eight patients undergoing palliative resection and cisplatin therapy (Serie...

Zhao You Tang, Hai Yan Zhou, Gang Zhao… in Medical Oncology and Tumor Pharmacotherapy (1991)

Article

A research for the relationship between human papillomavirus and human uterine cervical carcinoma

Biopsies from 318 cases with squamous cell carcinoma of the uterine cervix, 48 with cervical and vulvar condylomata, 14 with cervical intraepithelial neoplasia (CIN), 34 with chronic cervicitis and 24 with nor...

**gyi Si, Kun Lee, Ricai Han, Wei Zhang… in Journal of Cancer Research and Clinical On… (1991)

Article

A research for the relationship between human papillomavirus and human uterine cervical carcinoma

In order to elucidate the role of HPV-16 in the development of genital cancer, NIH3T3 cells were transfected by HPV-16 whole genome and its two early genes, E6-E7. Besides ordinary calcium phosphate/DNA coprec...

**gyi Si, Kun Lee, Wei Zhang, Ricai Han… in Journal of Cancer Research and Clinical On… (1991)

Article

Radioiodinated anti-hepatocellular carcinoma (HCC) ferritin Targeting therapy, tumor imaging and anti-antibody response in HCC patients with hepatic arterial infusion

Radioimmunoimaging and radioimmunotherapy with radioiodinated anti-(hepatocellular carcinoma ferritin) antibody (¹³¹I-or¹²⁵I-FtAb) have been applied in patients with primary liver cancer. A total of 41 patients w...

Zhen Fan, Zhaoyou Tang, Kangda Liu… in Journal of Cancer Research and Clinical On… (1992)

Article

Abstract form for the Irish Journal of Medical Science v workshop on gastroduodenal pathology and Helicobacter pylori July 5th — 7th 1992 — Dublin, Ireland

R. P. H. Logan, P. A. Gummett, M. M. Walker… in Irish Journal of Medical Science (1992)

Article

Growth-inhibitory effects of coumarin (1,2-benzopyrone) and 7-hydroxycoumarin on human malignant cell lines in vitro

Coumarin (1,2-benzopyrone) is a natural substance that has shown antitumor activity in vivo. The major human metabolite of coumarin, 7-hydroxycoumarin (7-HC), is the active form of the drug. While the exact me...

M. E. Marshall, K. Kervin, C. Benefield… in Journal of Cancer Research and Clinical On… (1994)

Article

Reduced hepatic LDL-receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase and sterol carrier protein-2 expression is associated with pregnancy loss in the diabetic rat

Hepatic low density lipoprotein receptor (LDLR), 3-hydroxy-3-methylglutaryl coenyzme A reductase (HMGR), cholesterol 7α-hydroxylase, and sterol carrier protein-2 are important proteins associated with the upta...

Mark P. McLean, Zhihong Zhao, Gene C. Ness in Endocrine (1995)

Article

Identification and functional analysis of multiple murine myeloperoxidase (MPO) promoters and comparison with the human MPO promoter region

Myeloperoxidase (MPO) is an important component of the oxidative antibacterial defense system of granulocytes. Mammalian MPO gene expression has been most extensively studied in human and murine cells. Transcr...

W-G Zhao, JP Lu, A Regmi, GE Austin in Leukemia (1997)

Article

Relationship of p215^BRCA1 to tyrosine kinase signaling pathways and the cell cycle in normal and transformed cells

We have analysed the relationship of the products of two genes, neu and BRCA1, known to be important in human breast cancer. Highly specific antibodies that recognized both the rodent and human form of the BRCA1 ...

Hong-Tao Zhang, **n Zhang, Hui-Zhen Zhao, Yuri Ka**o, Barbara L Weber… in Oncogene (1997)

Article

2-Chlorodeoxyadenosine therapy for idiopathic hypereosinophilic syndrome

Idiopathic hypereosinophilic syndrome (HES) is a rare disease with no established effective therapy. It has been reported that interleukin-5 (IL-5) produced by helper T cells plays a major role in the prolifer...

NT Ueno, S Zhao, LE Robertson, U Consoli, M Andreeff in Leukemia (1997)

Article

Differential expressions of cyclin A and the retinoblastoma gene product in histological subtypes of lung cancer cell lines

Cell-cycle-dependent phosphorylation of the tumor-suppressor protein product of the retinoblastoma gene (RB) is mediated by a family of cyclin-dependent kinases and cyclins. We examined the expressions of RB ...

Eiji Shimizu, MeiRong Zhao… in Journal of Cancer Research and Clinical On… (1997)

Article

AU-rich mRNA instability elements on human papillomavirus type 1 late mRNAs and c-fos mRNAs interact with the same cellular factors

Expression levels of human papillomavirus type 1 late genes are determined in part by an AU-rich inhibitory sequence in the 3′ untranslated region on the late mRNAs. Fine map** of the AU rich inhibitory sequ...

Marcus Sokolowski, Cui** Zhao, Wei Tan, Stefan Schwartz in Oncogene (1997)

Article

Cellular pharmacology of mitoxantrone in p-glycoprotein-positive and -negative human myeloid leukemic cell lines

Previous reports suggest that resistance to mitoxantrone in different tumor cell lines is unrelated to the overexpression of p-glycoprotein. In order to determine the role of p-glycoprotein in the cellular pha...

U Consoli, NT Van, N Neamati, R Mahadevia, M Beran, S Zhao, M Andreeff in Leukemia (1997)

Article

PCR display identifies tamoxifen induction of the novel angiogenic factor adrenomedullin by a non estrogenic mechanism in the human endometrium

Tamoxifen is currently the most widely used drug for the treatment of breast cancer, but there now exists considerable evidence that tamoxifen can also induce endometrial hyperplasia in pre menopausal women. W...

Yuan Zhao, Stephen Hague, Sanjiv Manek, Lyna Zhang, Roy Bicknell… in Oncogene (1998)

Article

Cloning and characterization of human and mouse telomerase RNA gene promoter sequences

Variation in telomerase activity is correlated with cellular senescence and tumour progression. However, although the enzymatic activity of telomerase has been well studied, very little is known about how expr...

Jiang-Qin Zhao, Stacey F Hoare, Robert McFarlane, Sharon Muir… in Oncogene (1998)

Article

Absence of autophosphorylation site Y882 in the p185^neu oncogene product correlates with a reduction of transforming potential

Autophosphorylation of type I receptor tyrosine kinases (RTKs) comprises one step in the signaling events mediated by erbB receptors such as p185^neu and EGFR. Previous analysis of p185^neu has indicated that there...

Hong-Tao Zhang, Donald M O'Rourke, Huizhen Zhao, Ramachandran Murali… in Oncogene (1998)

Article

Direct association of YY-1 with c-Myc and the E-box binding protein in regulation of glycophorin gene expression

We previously reported that YY-1, a versatile transcription factor, regulates expression of glycophorin gene by binding to its locus control region-like region (Gp-LCR) in combination with E-box binding protei...

Ji He Zhao, Toshiaki Inoue, Wataru Shoji, Yasuhisa Nemoto, Masuo Obinata in Oncogene (1998)