9 Result(s)
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Article
Stoyan Ivanov
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Article
Open AccessTrem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis
Atherosclerosis is driven by the expansion of cholesterol-loaded ‘foamy’ macrophages in the arterial intima. Factors regulating foamy macrophage differentiation and survival in plaque remain poorly understood....
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Percutaneous fixation of intraarticular joint-depression calcaneal fractures with different screw configurations – a biomechanical human cadaveric analysis
The aim of this study was to assess the biomechanical performance of different screw configurations for fixation of Sanders type II B joint-depression calcaneal fractures.
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Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation
Macrophages rely on tightly integrated metabolic rewiring to clear dying neighboring cells by efferocytosis during homeostasis and disease. Here we reveal that glutaminase-1-mediated glutaminolysis is critical...
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Open AccessBrown adipose tissue monocytes support tissue expansion
Monocytes are part of the mononuclear phagocytic system. Monocytes play a central role during inflammatory conditions and a better understanding of their dynamics might open therapeutic opportunities. In the p...
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Open AccessVisceral obesity and insulin resistance associate with CD36 deletion in lymphatic endothelial cells
Disruption of lymphatic lipid transport is linked to obesity and type 2 diabetes (T2D), but regulation of lymphatic vessel function and its link to disease remain unclear. Here we show that intestinal lymphati...
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Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression
Early atherosclerosis depends upon responses by immune cells resident in the intimal aortic wall. Specifically, the healthy intima is thought to be populated by vascular dendritic cells (DCs) that, during hype...
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Myeloid cells pave the way for lymphatic system development and maintenance
The maintenance of tissue homeostasis is indispensable for health. In particular, removal of toxic compounds from cells and organs is a vital process for the organism. The lymphatic vasculature works in order ...
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Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
By comparing gene-expression profiles, Randolph and colleagues distinguish different types of macrophages and pinpoint the differences between macrophages and dendritic cells.
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Glycosyltransferase and sulfotransferase gene expression profiles in human monocytes, dendritic cells and macrophages
Using a focused glycan-gene microarray, we compared the glycosyltransferase (GT) and sulfotransferase gene expression profiles of human monocytes, dendritic cells (DCs) and macrophages (Mϕs), isolated or diffe...
