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  1. No Access

    Article

    Requirement of mitogen-activated protein kinase for collagenase production by the fibronectin fragment in human articular chondrocytes in culture

    Fibronectin fragments have been shown to up-regulate matrix metalloproteinase production in chondrocytes. We investigated the roles of mitogen-activated protein kinase (MAPK) pathways activated by the COOH-ter...

    Tadashi Yasuda, Sohel M. Julovi, Teruko Hiramitsu, Makoto Yoshida… in Modern Rheumatology (2004)

  2. No Access

    Article

    Hyaluronan inhibits IL-1β-stimulated collagenase production via down-regulation of phosphorylated p38 in SW-1353 human chondrosarcoma cells

    We investigated the intracellular mechanism for the inhibitory effects of hyaluronan (HA) on interleukin-1β (IL-1β)-stimulated collagenase-1 and -3 (matrix metalloproteinases (MMPs)-1 and -13) production in a ...

    Sohel M. Julovi, Hiromu Ito, Teruko Hiramitsu, Tadashi Yasuda… in Modern Rheumatology (2008)

  3. Article

    Open Access

    Activated Protein C Inhibits Proliferation and Tumor Necrosis Factor α-Stimulated Activation of p38, c-Jun NH2-Terminal Kinase (JNK) and Akt in Rheumatoid Synovial Fibroblasts

    Synovial fibroblast proliferation Is a hallmark of the Invasive pannus in the rheumatoid joint. Activated protein C (APC) is a natural anticoagulant that exerts antiinflammatory and cyto-protective effects in ...

    Sohel M. Julovi, Kaitlin Shen, Kelly McKelvey, Nikita Minhas… in Molecular Medicine (2013)

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  4. Article

    Open Access

    Inhibition of basal-like breast cancer growth by FTY720 in combination with epidermal growth factor receptor kinase blockade

    New molecular targets are needed for women with triple-negative breast cancer (TNBC). This pre-clinical study investigated the combination of the EGFR inhibitor gefitinib with the sphingosine kinase (SphK) inh...

    Janet L. Martin, Sohel M. Julovi, Mike Z. Lin… in Breast Cancer Research (2017)

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