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Article
Hyaluronan inhibits IL-1β-stimulated collagenase production via down-regulation of phosphorylated p38 in SW-1353 human chondrosarcoma cells
We investigated the intracellular mechanism for the inhibitory effects of hyaluronan (HA) on interleukin-1β (IL-1β)-stimulated collagenase-1 and -3 (matrix metalloproteinases (MMPs)-1 and -13) production in a ...
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Article
Requirement of mitogen-activated protein kinase for collagenase production by the fibronectin fragment in human articular chondrocytes in culture
Fibronectin fragments have been shown to up-regulate matrix metalloproteinase production in chondrocytes. We investigated the roles of mitogen-activated protein kinase (MAPK) pathways activated by the COOH-ter...