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  1. Article

    Open Access

    p21-activated kinase 4 controls the aggregation of α-synuclein by reducing the monomeric and aggregated forms of α-synuclein: involvement of the E3 ubiquitin ligase NEDD4-1

    Aggregation of misfolded alpha-synuclein (α-synuclein) is a central player in the pathogenesis of neurodegenerative diseases. Therefore, the regulatory mechanism underlying α-synuclein aggregation has been int...

    So-Yoon Won, Jung-** Park, Soon-Tae You, Jong-A Hyeun… in Cell Death & Disease (2022)

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  2. No Access

    Article

    Withaferin A mitigates metastatic traits in human oral squamous cell carcinoma caused by aberrant claudin-1 expression

    Abnormal expression of claudin-1 (CLDN1) has important roles in carcinogenesis and metastasis in various cancers. The role of CLDN1 in human oral squamous cell carcinoma (OSCC) remains unknown. Here, we report...

    Ji-Ae Shin, Lee-Han Kim, Mi Heon Ryu, So-Young Choi… in Cell Biology and Toxicology (2022)

  3. No Access

    Article

    EW-7197 inhibits hepatic, renal, and pulmonary fibrosis by blocking TGF-β/Smad and ROS signaling

    Fibrosis is an inherent response to chronic damage upon immense apoptosis or necrosis. Transforming growth factor-beta1 (TGF-β1) signaling plays a key role in the fibrotic response to chronic liver injury. To ...

    Sang-A Park, Min-** Kim, So-Yeon Park… in Cellular and Molecular Life Sciences (2015)

  4. Article

    Open Access

    Long term conservation of human metabolic phenotypes and link to heritability

    Changes in an individual’s human metabolic phenotype (metabotype) over time can be indicative of disorder-related modifications. Studies covering several months to a few years have shown that metabolic profil...

    Noha A. Yousri, Gabi Kastenmüller, Christian Gieger, So-Youn Shin… in Metabolomics (2014)

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  5. No Access

    Article

    Enhanced cytotoxicity of 5-FU by bFGF through up-regulation of uridine phosphorylase 1

    Anti cancer agent 5-FU (Fluoro Uracil) is a prodrug that can be metabolized and then activated to interfere with RNA and DNA homeostasis. However, the majority of administered 5-FU is known to be catabolized in v...

    Young-Sam Im, Hea Kyeong Shin, Hye-Ryun Kim, So-Hee Jeong… in Molecules and Cells (2009)

  6. No Access

    Article

    On-chip Escherichia coli culture, purification, and detection of expressed proteins

    In a recent study, we reported the results of a rapid high-throughput expression analysis of the affinity-tagged proteins present in total cell lysates, using a surface plasmon resonance (SPR) imaging protein ...

    Moonil Kim, So-Young Lee, Hyunju Choi, Yong-Beom Shin… in European Biophysics Journal (2006)